(Q46588782)

23 December 2017

title

Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma (English)

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23 December 2017

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7

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23 December 2017

author name string

Mark A Birrell

1

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23 December 2017

Elizabeth Hardaker

2

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23 December 2017

Sissie Wong

3

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23 December 2017

Kerryn McCluskie

4

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23 December 2017

Matthew Catley

5

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23 December 2017

Jorge De Alba

6

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23 December 2017

Saleem Haj-Yahia

8

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23 December 2017

K Tao Pun

9

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23 December 2017

Clarissa J Watts

10

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23 December 2017

Robert J Shaw

11

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23 December 2017

Tony J Savage

12

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23 December 2017

Maria G Belvisi

13

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23 December 2017

language of work or name

English

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publication date

7 July 2005

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23 December 2017

American Journal of Respiratory and Critical Care Medicine

published in

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23 December 2017

volume

172

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23 December 2017

issue

8

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23 December 2017

page(s)

962-971

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23 December 2017

Series introduction: the transcription factor NF-kappaB and human disease

cites work

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Activation and localization of transcription factor, nuclear factor-kappaB, in asthma

21 January 2018

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Effects of budesonide and formoterol on NF-kappaB, adhesion molecules, and cytokines in asthma

21 January 2018

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https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Rapid activation of nuclear factor-kappaB in airway epithelium in a murine model of allergic airway inflammation

21 January 2018

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Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation

21 January 2018

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https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Protection of mice from allergen-induced asthma by selenite: prevention of eosinophil infiltration by inhibition of NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat.

21 January 2018

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https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

NF-kappaB at the crossroads of life and death

21 January 2018

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https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

NF-kappaB regulation in the immune system

21 January 2018

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Signal transduction. Docking IkappaB kinases.

21 January 2018

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https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation

21 January 2018

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https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

IKK1-deficient mice exhibit abnormal development of skin and skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

21 January 2018

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https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Limb and skin abnormalities in mice lacking IKKalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokin

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Efficacy of Alendronate in Adults with Cystic Fibrosis with Low Bone Density

21 January 2018

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https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Functional characterization and biomarker identification in the Brown Norway model of allergic airway inflammation

21 January 2018

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Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats

21 January 2018

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https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Quantifying proliferation of cultured human and rabbit airway smooth muscle cells in response to serum and platelet-derived growth factor

21 January 2018

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https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM-CSF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

21 January 2018

Signaling to NF-kappaB

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

Airway eosinophils, T cells, Th2-type cytokine mRNA, and hyperreactivity in response to aerosol challenge of allergic mice with previously established pulmonary inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

RPR 106541, a novel, airways-selective glucocorticoid: effects against antigen-induced CD4+ T lymphocyte accumulation and cytokine gene expression in the Brown Norway rat lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.200412-1647OC

10.1164/RCCM.200412-1647OC

21 January 2018

Identifiers

DOI

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23 December 2017

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23 December 2017