(Q46602331)

23 December 2017

title

Studies addressing the importance of charge in the binding of fosmidomycin-like molecules to deoxyxylulosephosphate reductoisomerase (English)

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23 December 2017

author name string

Johann Perruchon

1

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23 December 2017

Regina Ortmann

2

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23 December 2017

Mirko Altenkämper

3

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23 December 2017

Katrin Silber

4

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23 December 2017

Jochen Wiesner

5

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23 December 2017

Hassan Jomaa

6

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23 December 2017

Gerhard Klebe

7

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23 December 2017

Martin Schlitzer

8

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23 December 2017

publication date

1 August 2008

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23 December 2017

published in

ChemMedChem

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23 December 2017

volume

3

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23 December 2017

issue

8

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23 December 2017

page(s)

1232-1241

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23 December 2017

The plastid-derived organelle of protozoan human parasites as a target of established and emerging drugs

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Isoprenoid biosynthesis of the apicoplast as drug target

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https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs.

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https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Isoprenoid biosynthetic pathways as anti-infective drug targets

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https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme.

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https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

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https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children

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https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria

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https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Short-course regimens of artesunate-fosmidomycin in treatment of uncomplicated Plasmodium falciparum malaria

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development

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https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Alkoxycarbonyloxyethyl ester prodrugs of FR900098 with improved in vivo antimalarial activity

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https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

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https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Distributed automated docking of flexible ligands to proteins: Parallel applications of AutoDock 2.4

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Automated docking of flexible ligands: applications of AutoDock

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https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

MOPAC: a semiempirical molecular orbital program

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https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

MAB, a generally applicable molecular force field for structure modelling in medicinal chemistry.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Double ester prodrugs of FR900098 display enhanced in-vitro antimalarial activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200800083

7 January 2021

Identifiers

DOI

10.1002/CMDC.200800083

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23 December 2017

1 reference

23 December 2017