(Q36066272)

12 August 2017

1 reference

title

The plastid-derived organelle of protozoan human parasites as a target of established and emerging drugs (English)

1 reference

12 August 2017

Jochen Wiesner

1

1 reference

12 August 2017

Frank Seeber

series ordinal

2

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12 August 2017

language of work or name

English

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publication date

1 February 2005

1 reference

Expert Opinion on Therapeutic Targets

12 August 2017

published in

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12 August 2017

volume

9

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12 August 2017

issue

1

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12 August 2017

page(s)

23-44

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Medical need, scientific opportunity and the drive for antimalarial drugs

12 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Antimalarial drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Therapy of falciparum malaria in sub-saharan Africa: from molecule to policy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

21 January 2018

New Antimalarial Drugs

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Toxoplasma gondii: from animals to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Cryptosporidiosis and the challenges of chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Comparative analysis of apicomplexa and genomic diversity in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Cyclospora cayetanensis: a review of an emerging parasitic coccidian

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Progress with parasite plastids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

The apicoplast: A plastid in Plasmodium falciparum and other apicomplexan parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

On the evolutionary origins of apicoplasts: revisiting the rhodophyte vs. chlorophyte controversy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

A circular DNA in malaria parasites encodes an RNA polymerase like that of prokaryotes and chloroplasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Genome sequence of the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Deciphering apicoplast targeting signals--feature extraction from nuclear-encoded precursors of Plasmodium falciparum apicoplast proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

The apicoplast as an antimalarial drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Biosynthetic pathways of plastid-derived organelles as potential drug targets against parasitic apicomplexa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Mitochondrial and plastid functions as antimalarial drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

A plastid organelle as a drug target in apicomplexan parasites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

The plastid DNA of the malaria parasite Plasmodium falciparum is replicated by two mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Antimalarial activity of rifampicin in vitro and in rodent models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Treatment of malaria tropica with a fixed combination of rifampicin, co-trimoxazole and isoniazid: a clinical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Apicoplast genome of the coccidian Eimeria tenella

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Mitochondria as the site of action of tetracycline on Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

An rRNA mutation identifies the apicoplast as the target for clindamycin in Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Thiostrepton binds to malarial plastid rRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Effects of interruption of apicoplast function on malaria infection, development, and transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Spatial simulation of malaria transmission and its control by malaria transmission blocking vaccination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Potentiation of the antimalarial activity of atovaquone by doxycycline against Plasmodium falciparum in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Increased antimalarial activity of azithromycin during prolonged exposure of Plasmodium falciparum in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

The in vitro antimalarial activity of chloramphenicol against Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

In vitro and in vivo synergy of fosmidomycin, a novel antimalarial drug, with clindamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Biosynthesis of isoprenoids: Crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritol kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

A proposed mechanism for the reductive ring opening of the cyclodiphosphate MEcPP, a crucial transformation in the new DXP/MEP pathway to isoprenoids based on modeling studies and feeding experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Microbial isoprenoid biosynthesis and human gammadelta T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Apicoplast fatty acid biosynthesis as a target for medical intervention in apicomplexan parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Apicomplexan plastids as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Forty years of bacterial fatty acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Subcellular localization of acetyl-CoA carboxylase in the apicomplexan parasite Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Growth of Toxoplasma gondii is inhibited by aryloxyphenoxypropionate herbicides targeting acetyl-CoA carboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

The carboxyltransferase activity of the apicoplast acetyl-CoA carboxylase of Toxoplasma gondii is the target of aryloxyphenoxypropionate inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Herbicide safety relative to common targets in plants and mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

An isoleucine/leucine residue in the carboxyltransferase domain of acetyl-CoA carboxylase is critical for interaction with aryloxyphenoxypropionate and cyclohexanedione inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Molecular basis of triclosan activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Delivery of antimicrobials into parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Mutational analysis of the triclosan-binding region of enoyl-ACP (acyl-carrier protein) reductase from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Triclosan as a systemic antibacterial agent in a mouse model of acute bacterial challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Membranotropic effects of the antibacterial agent Triclosan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Interaction of triclosan with eukaryotic membrane lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Triclosan as a substrate and inhibitor of 3'-phosphoadenosine 5'-phosphosulfate-sulfotransferase and UDP-glucuronosyl transferase in human liver fractions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Multiple triclosan targets in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Isonicotinic acid hydrazide: an anti-tuberculosis drug inhibits malarial transmission in the mosquito gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Current progress in the fatty acid metabolism in Cryptosporidium parvum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Protein N-terminal methionine excision.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Seeking new targets for antiparasitic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

An improved crystal form of Plasmodium falciparum peptide deformylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Theories on malarial pigment formation and quinoline action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Mining the Plasmodium genome database to define organellar function: what does the apicoplast do?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Enzymes for heme biosynthesis are found in both the mitochondrion and plastid of the malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Therapeutic responses to antimalarial and antibacterial drugs in vivax malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Doxycycline as first line malarial prophylaxis: how safe is it?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Clindamycin as an antimalarial drug: review of clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Three-day quinine-clindamycin treatment of uncomplicated falciparum malaria imported from the tropics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

In vitro activity and interaction of clindamycin combined with dihydroartemisinin against Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Frequency of antibiotic-associated diarrhoea in 2462 antibiotic-treated hospitalized patients: a prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Synthesis and antimicrobial activity of clindamycin analogs: pirlimycin, a potent antibacterial agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in western Kenya

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Malaria prophylaxis using azithromycin: a double-blind, placebo-controlled trial in Irian Jaya, Indonesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Therapeutic responses to antibacterial drugs in vivax malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Triangular test applied to the clinical trial of azithromycin against relapses in Plasmodium vivax infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Tolerability of azithromycin as malaria prophylaxis in adults in northeast papua, indonesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Short course of azithromycin/artesunate against falciparum malaria: no full protection against recrudescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Antimalarial drug discovery: efficacy models for compound screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Failure of erythromycin to improve chloroquine treatment of Plasmodium falciparum malaria in Kenya

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Ciprofloxacin does not achieve radical cure of Plasmodium falciparum infection in Sierra Leone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Adverse effect of rifampin on quinine efficacy in uncomplicated falciparum malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

21 January 2018

Fosmidomycin for malaria

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Fosmidomycin, a novel chemotherapeutic agent for malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Combination therapy counteracts the enhanced transmission of drug-resistant malaria parasites to mosquitoes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Processing of an apicoplast leader sequence in Plasmodium falciparum and the identification of a putative leader cleavage enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

The human malaria parasite Plasmodium falciparum has distinct organelle-specific lipoylation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

Apicomplexan parasites contain a single lipoic acid synthase located in the plastid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

EARLY EVOLUTIONARY HISTORY OF DINOFLAGELLATES AND APICOMPLEXANS (ALVEOLATA) AS INFERRED FROM HSP90 AND ACTIN PHYLOGENIES1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.23

21 January 2018

Identifiers

DOI

10.1517/14728222.9.1.23

1 reference

12 August 2017

1 reference