(Q46602513)

23 December 2017

title

Regulatory phosphorylation of cyclin-dependent kinase 2: insights from molecular dynamics simulations (English)

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23 December 2017

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2

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23 December 2017

Michal Otyepka

series ordinal

3

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23 December 2017

author name string

Iveta Bártová

series ordinal

1

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23 December 2017

publication date

10 May 2008

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23 December 2017

Journal of Molecular Modeling

published in

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23 December 2017

volume

14

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issue

8

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23 December 2017

page(s)

761-768

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23 December 2017

https://scigraph.springernature.com/pub.10.1007/s00894-008-0312-1

exact match

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cites work

Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C

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A predictive scale for evaluating cyclin-dependent kinase substrates. A comparison of p34cdc2 and p33cdk2.

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Cyclin-dependent kinases: engines, clocks, and microprocessors

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The protein kinase complement of the human genome

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The mechanism of inhibition of the cyclin-dependent kinase-2 as revealed by the molecular dynamics study on the complex CDK2 with the peptide substrate HHASPRK

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Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

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12 December 2020

Structural studies on phospho-CDK2/cyclin A bound to nitrate, a transition state analogue: implications for the protein kinase mechanism

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12 December 2020

Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members

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12 December 2020

Pharmacological inhibitors of cyclin-dependent kinases

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12 December 2020

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

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12 December 2020

Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2alpha

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12 December 2020

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

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12 December 2020

Catalytic mechanism of phosphorylase kinase probed by mutational studies

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12 December 2020

Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle

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12 December 2020

Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity

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12 December 2020

Computational study of the phosphoryl transfer catalyzed by a cyclin-dependent kinase.

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12 December 2020

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15

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12 December 2020

Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation

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12 December 2020

Activation and inhibition of cyclin-dependent kinase-2 by phosphorylation; a molecular dynamics study reveals the functional importance of the glycine-rich loop

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How does the cAMP-dependent protein kinase catalyze the phosphorylation reaction: an ab initio QM/MM study

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Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials

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Crystal structure of cyclin-dependent kinase 2

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Kinetic mechanism of activation of the Cdk2/cyclin A complex. Key role of the C-lobe of the Cdk.

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12 December 2020

How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A.

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Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15

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12 December 2020

Principles of CDK regulation

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12 December 2020

Use of an oriented peptide library to determine the optimal substrates of protein kinases

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12 December 2020

Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis

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12 December 2020

Structural basis of cyclin-dependent kinase activation by phosphorylation

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12 December 2020

Different mechanisms of CDK5 and CDK2 activation as revealed by CDK5/p25 and CDK2/cyclin A dynamics

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12 December 2020

10.1007/S00894-008-0312-1

Identifiers

DOI

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23 December 2017

PubMed ID

18470542

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23 December 2017