(Q46608687)

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Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation.

scientific article published on 7 May 2008

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18461448%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Inhibition of Wnt and PI3K signaling modulates GSK-3beta activity and induces morphological changes in cortical neurons: role of tau phosphorylation (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18461448%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

phosphorylation

1 reference

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Karla Hernández-Fonseca

2

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Europe PubMed Central

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7 January 2020

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Octavio Mercado-Gómez

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18461448%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Alexa Villavicencio-Queijeiro

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18461448%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Lourdes Massieu

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18461448%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Jesús Chimal-Monroy

5

1 reference

Europe PubMed Central

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7 January 2020

Clorinda Arias

6

1 reference

Europe PubMed Central

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7 January 2020

publication date

7 May 2008

1 reference

Europe PubMed Central

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7 January 2020

Neurochemical Research

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18461448%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

33

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Europe PubMed Central

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7 January 2020

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18461448%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1599-1609

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18461448%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Signal transduction by the Wnt family of ligands

1 reference

https://api.crossref.org/works/10.1007%2FS11064-008-9714-9

21 January 2018

Feed-forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro

1 reference

https://api.crossref.org/works/10.1007%2FS11064-008-9714-9

21 January 2018

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1007%2FS11064-008-9714-9

21 January 2018

Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling function in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of Wnt signaling in development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signalling regulates adult hippocampal neurogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: a personal historical perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-catenin: a key mediator of Wnt signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vital elements of the Wnt-Frizzled signaling pathway in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular effects of lithium

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A molecular mechanism for the effect of lithium on development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt factors in axonal remodelling and synaptogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt participation in the Wnt signaling pathway through Dishevelled

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lithium inhibits glycogen synthase kinase-3 by competition for magnesium.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase 3: a drug target for CNS therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functions of PI 3-kinase in development of the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted antagonists of the Wnt signalling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotoxicity in Alzheimer's disease: the Wnt signaling pathway as a molecular target

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibition of phosphatidylinositol-3-kinase induces neurite retraction and activates GSK3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting WNT, protein kinase B, and mitochondrial membrane integrity to foster cellular survival in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormalities of Wnt signalling in schizophrenia--evidence for neurodevelopmental abnormality

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid peptide fragment 25-35 potentiates the calcium-dependent release of excitatory amino acids from depolarized hippocampal slices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling through beta-catenin and Lef/Tcf

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted Frizzled-related proteins: searching for relationships and patterns

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of Wnt-1 in schizophrenic brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation determines two distinct species of Tau in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inositol monophosphatase inhibitors--lithium mimetics?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GSK3 takes centre stage more than 20 years after its discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Okadaic acid induces early changes in microtubule-associated protein 2 and tau phosphorylation prior to neurodegeneration in cultured cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnts: up-and-coming at the synapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegenerative tauopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wortmannin blocks goldfish retinal phosphatidylinositol 3-kinase and neurite outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCF transcription factors, mediators of Wnt-signaling in development and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphoinositide 3-kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of endoplasmic reticulum calcium stores is involved in neuronal death induced by glycolysis inhibition in cultured hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18461448

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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