(Q46619033)

23 December 2017

title

Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis (English)

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23 December 2017

author name string

John D Ryan

1

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23 December 2017

Eleanor Ryan

2

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23 December 2017

Aurelie Fabre

3

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23 December 2017

Matthew W Lawless

4

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23 December 2017

John Crowe

5

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23 December 2017

language of work or name

English

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publication date

1 October 2010

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23 December 2017

published in

Hepatology

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23 December 2017

volume

52

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23 December 2017

issue

4

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23 December 2017

page(s)

1266-1273

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23 December 2017

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

cites work

1 reference

Fine tuning and cross-talking of TGF-beta signal by inhibitory Smads

21 January 2018

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Disorders of iron metabolism

21 January 2018

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7 January 2021

Hereditary hemochromatosis--a new look at an old disease

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7 January 2021

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

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7 January 2021

The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression

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Physiologic systemic iron metabolism in mice deficient for duodenal Hfe

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7 January 2021

Hfe acts in hepatocytes to prevent hemochromatosis.

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7 January 2021

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

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7 January 2021

Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

1 reference

7 January 2021

Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation

1 reference

7 January 2021

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

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7 January 2021

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

1 reference

7 January 2021

Decreased liver hepcidin expression in the Hfe knockout mouse

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7 January 2021

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

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7 January 2021

The molecular defect in hypotransferrinemic mice

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7 January 2021

Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice.

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7 January 2021

Long-term sequelae of HFE deletion in C57BL/6 x 129/O1a mice, an animal model for hereditary haemochromatosis

1 reference

7 January 2021

Fine tuning of hepcidin expression by positive and negative regulators

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7 January 2021

The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes

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7 January 2021

Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression

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7 January 2021

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

1 reference

7 January 2021

Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

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7 January 2021

A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells

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7 January 2021

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

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7 January 2021

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

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7 January 2021

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

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7 January 2021

BMP6 orchestrates iron metabolism.

1 reference

7 January 2021

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

1 reference

7 January 2021

Common variants in the BMP2, BMP4, and HJV genes of the hepcidin regulation pathway modulate HFE hemochromatosis penetrance

1 reference

7 January 2021

A common SNP near BMP2 is associated with severity of the iron burden in HFE p.C282Y homozygous patients: a follow-up study.

1 reference

7 January 2021

BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression.

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7 January 2021

Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis

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7 January 2021

Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis

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7 January 2021

An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group

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7 January 2021

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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7 January 2021

Clinical expression of haemochromatosis in Irish C282Y homozygotes identified through family screening.

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7 January 2021

Underdiagnosis of hereditary haemochromatosis: lack of presentation or penetration?

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7 January 2021

Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis

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7 January 2021

Serum hepcidin levels are innately low in HFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levels

1 reference

7 January 2021

The Smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor: potential clinical implications

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7 January 2021

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

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7 January 2021

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7 January 2021

Smad6 inhibits signalling by the TGF-beta superfamily.

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7 January 2021

Negative regulation of TGF-beta receptor/Smad signal transduction.

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7 January 2021

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

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7 January 2021

Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats

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7 January 2021

Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage

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7 January 2021

Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

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7 January 2021

Excess iron induces hepatic oxidative stress and transforming growth factor beta1 in genetic hemochromatosis.

1 reference

7 January 2021

Identifiers

DOI

10.1002/HEP.23814

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23 December 2017

PubMed ID

20658468

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23 December 2017