(Q46624550)

English

Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation

scientific article published on 14 March 2008

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scholarly article

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation (English)

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

1 reference

based on heuristic

inferred from title

Diastolic function

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based on heuristic

inferred from title

9

object named as

Gerd Hasenfuss

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Europe PubMed Central

PubMed publication ID

23 December 2017

author name string

Samuel Sossalla

1

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

Stefan Wagner

2

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

Eva C L Rasenack

3

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

Hanna Ruff

4

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

Sarah L Weber

5

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

Friedrich A Schöndube

6

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

Theodor Tirilomis

7

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

Gero Tenderich

8

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

Luiz Belardinelli

10

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

Lars S Maier

11

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

publication date

14 March 2008

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

Journal of Molecular and Cellular Cardiology

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

45

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

1

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

32-43

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium.

1 reference

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7 January 2021

Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes

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7 January 2021

Na channels that remain open throughout the cardiac action potential plateau.

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Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome

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Late sodium current in the pathophysiology of cardiovascular disease: consequences of sodium-calcium overload

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A persistent sodium current in rat ventricular myocytes

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Na(+) current in human ventricle: implications for sodium loading and homeostasis

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7 January 2021

Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged

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7 January 2021

Increased late sodium current in myocytes from a canine heart failure model and from failing human heart.

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Repolarization abnormalities in cardiomyocytes of dogs with chronic heart failure: role of sustained inward current.

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Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability.

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7 January 2021

Hypoxia increases persistent sodium current in rat ventricular myocytes.

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Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes.

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7 January 2021

Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction.

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7 January 2021

Rate dependence of [Na+]i and contractility in nonfailing and failing human myocardium

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7 January 2021

Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial

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7 January 2021

Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina

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7 January 2021

Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

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7 January 2021

Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome

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7 January 2021

Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes

1 reference

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7 January 2021

Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial

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7 January 2021

Protective effects of ranolazine, a novel anti-ischemic drug, on the hydrogen peroxide-induced derangements in isolated, perfused rat heart: comparison with dichloroacetate

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7 January 2021

Effects of ranolazine on left ventricular regional diastolic function in patients with ischemic heart disease

1 reference

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7 January 2021

Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium.

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7 January 2021

Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes

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7 January 2021

Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels

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7 January 2021

Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts.

1 reference

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7 January 2021

Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine

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7 January 2021

Effects of amiodarone on cardiac electrophysiology and inducibility of arrhythmias in chronically infarcted dogs: late arrhythmias, haemodynamics, and sympatholytic actions

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7 January 2021

Late sodium current is a novel target for amiodarone: studies in failing human myocardium

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Effect of maximal coronary vasodilation on transmural myocardial perfusion during tachycardia in dogs with left ventricular hypertrophy.

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Can novel therapies for arrhythmias caused by spontaneous sarcoplasmic reticulum Ca2+ release be developed using mouse models?

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Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle

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Cardioprotective effects of ranolazine (RS-43285) in the isolated perfused rabbit heart.

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Ranolazine attenuates palmitoyl-L-carnitine-induced mechanical and metabolic derangement in the isolated, perfused rat heart

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Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure

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Anemone toxin (ATX II)-induced increase in persistent sodium current: effects on the firing properties of rat neocortical pyramidal neurones.

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Studies on the Mechanism of the Positive Inotropic Effect of ATX II (Anemonia sulcata) on Isolated Guinea Pig Atria

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The effects of the Anemonia sulcata toxin (ATX II) on membrane currents of isolated mammalian myocytes

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Protection against myocardial ischemic/reperfusion injury by inhibitors of two separate pathways of Na+ entry.

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Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading.

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The role of the Na+ channel in the accumulation of intracellular Na+ during myocardial ischemia: consequences for post-ischemic recovery.

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Acute and chronic hypoxic regulation of recombinant hNa(v)1.5 alpha subunits

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Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine

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Effect of hydrogen peroxide on persistent sodium current in guinea pig ventricular myocytes

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Alterations of sodium channel kinetics and gene expression in the postinfarction remodeled myocardium

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Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action

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Identifiers

10.1016/J.YJMCC.2008.03.006

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/18439620

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