(Q46628713)

English

Solution conformations and dynamics of ABL kinase-inhibitor complexes determined by NMR substantiate the different binding modes of imatinib/nilotinib and dasatinib

scientific article published on 22 April 2008

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scholarly article

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

Solution conformations and dynamics of ABL kinase-inhibitor complexes determined by NMR substantiate the different binding modes of imatinib/nilotinib and dasatinib (English)

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

Stephan Grzesiek

6

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

author name string

Navratna Vajpai

1

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

André Strauss

2

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

Gabriele Fendrich

3

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

Sandra W Cowan-Jacob

4

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

Paul W Manley

5

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

Wolfgang Jahnke

7

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

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publication date

22 April 2008

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

Journal of Biological Chemistry

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

283

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

26

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

18292-18302

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

Chronic myeloid leukaemia as a model of disease evolution in human cancer

1 reference

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1 reference

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21 January 2018

The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants

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21 January 2018

In silico profiling of tyrosine kinases binding specificity and drug resistance using Monte Carlo simulations with the ensembles of protein kinase crystal structures.

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21 January 2018

Chemical proteomic analysis reveals alternative modes of action for pyrido[2,3-d]pyrimidine kinase inhibitors.

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A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases

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NMR characterization of kinase p38 dynamics in free and ligand-bound forms

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21 January 2018

Efficient uniform isotope labeling of Abl kinase expressed in Baculovirus-infected insect cells

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Amino-acid-type selective isotope labeling of proteins expressed in Baculovirus-infected insect cells useful for NMR studies

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The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation

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21 January 2018

NMR View: A computer program for the visualization and analysis of NMR data

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Measurement of J and dipolar couplings from simplified two-dimensional NMR spectra

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Efficient analysis of macromolecular rotational diffusion from heteronuclear relaxation data

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Tunable alignment of macromolecules by filamentous phage yields dipolar coupling interactions

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21 January 2018

Direct measurement of distances and angles in biomolecules by NMR in a dilute liquid crystalline medium

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21 January 2018

Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR.

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21 January 2018

Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.

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21 January 2018

Intrinsic dynamics of an enzyme underlies catalysis

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c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M801337200

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/18434310

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