(Q46629439)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

MAC inhibitors antagonize the pro-apoptotic effects of tBid and disassemble Bax / Bak oligomers (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

author name string

Oscar Teijido

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Oygul Mirzalieva

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Laurent M Dejean

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Evgeny V Pavlov

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Bruno Antonsson

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Kathleen W Kinnally

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

publication date

23 December 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

Journal of Bioenergetics and Biomembranes

3 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

volume

49

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

page(s)

65-74

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26698318%20AND%20SRC:MED&resulttype=core&format=json

Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies

3 March 2020

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Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

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Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel

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Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

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Bax dimerizes via a symmetric BH3:groove interface during apoptosis

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After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

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Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC.

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Still embedded together binding to membranes regulates Bcl-2 protein interactions.

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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The cardiolipin-binding domain of Bid affects mitochondrial respiration and enhances cytochrome c release

21 January 2018

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Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

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Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release

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Many players in BCL-2 family affairs

21 January 2018

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Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties

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PubMed

https://pubmed.ncbi.nlm.nih.gov/26698318