(Q46652385)

24 December 2017

title

The de novo synthesis of GDP-fucose is essential for flagellar adhesion and cell growth in Trypanosoma brucei (English)

1 reference

24 December 2017

GDP-mannose 4,6 dehydratase

main subject

Trypanosoma brucei

0 references

1 reference

GeneDB

6 February 2019

GDP-L-fucose synthetase

1 reference

GeneDB

GDP-L-fucose synthetase, putative

6 February 2019

0 references

GDP-mannose 4,6 dehydratase, putative

0 references

1 reference

2

1 reference

24 December 2017

Michael J. Ferguson

series ordinal

3

1 reference

24 December 2017

author name string

Daniel C Turnock

series ordinal

1

1 reference

24 December 2017

language of work or name

English

0 references

publication date

19 July 2007

1 reference

24 December 2017

Journal of Biological Chemistry

published in

1 reference

24 December 2017

volume

282

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24 December 2017

issue

39

1 reference

24 December 2017

page(s)

28853-28863

1 reference

24 December 2017

Glycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sickness

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Glycoconjugate structures of parasitic protozoa

21 January 2018

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Glycoinositolphospholipids, free and as anchors of proteins, in Trypanosoma cruzi

21 January 2018

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Galactofuranose metabolism: a potential target for antimicrobial chemotherapy

21 January 2018

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Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness

21 January 2018

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Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite.

21 January 2018

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Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei

21 January 2018

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Essential roles for GPI-anchored proteins in African trypanosomes revealed using mutants deficient in GPI8

21 January 2018

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Properties of GDP-mannose pyrophosphorylase, a critical enzyme and drug target in Leishmania mexicana

21 January 2018

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Characterisation of a Leishmania mexicana knockout lacking guanosine diphosphate-mannose pyrophosphorylase

21 January 2018

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Glycosylation defects and virulence phenotypes of Leishmania mexicana phosphomannomutase and dolicholphosphate-mannose synthase gene deletion mutants

21 January 2018

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Disruption of mannose activation in Leishmania mexicana: GDP-mannose pyrophosphorylase is required for virulence, but not for viability

21 January 2018

1 reference

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The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei

21 January 2018

1 reference

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Galactose starvation in a bloodstream form Trypanosoma brucei UDP-glucose 4'-epimerase conditional null mutant

21 January 2018

1 reference

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The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology.

21 January 2018

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Nucleotide sugar transporters: biological and functional aspects

21 January 2018

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Nucleotide sugar transporters of the Golgi apparatus

21 January 2018

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Fucose: biosynthesis and biological function in mammals

21 January 2018

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Fucosylation in prokaryotes and eukaryotes

21 January 2018

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Cloning and expression of Helicobacter pylori GDP-l-fucose synthesizing enzymes (GMD and GMER) in Saccharomyces cerevisiae

21 January 2018

1 reference

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Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro

21 January 2018

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Synthesis of GDP-L-fucose by the human FX protein

21 January 2018

1 reference

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Purification to apparent homogeneity and properties of pig kidney L-fucose kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme

21 January 2018

1 reference

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Interaction of GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase with GDP-mannose-4,6-dehydratase stabilizes the enzyme activity for formation of GDP-fucose from GDP-mannose.

21 January 2018

1 reference

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The Genome of the African Trypanosome Trypanosoma brucei

21 January 2018

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Comparative genomics of trypanosomatid parasitic protozoa

21 January 2018

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The genome of the kinetoplastid parasite, Leishmania major

21 January 2018

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Structural analysis of the N-glycans of the major cysteine proteinase of Trypanosoma cruzi. Identification of sulfated high-mannose type oligosaccharides.

21 January 2018

1 reference

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Cell surface antigens of Trypanosoma cruzi: use of monoclonal antibodies to identify and isolate an epimastigote specific glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Studies on the structure of a phosphoglycoprotein from the parasitic protozoan Trypanosoma cruzi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Deletion of an immunodominant Trypanosoma cruzi surface glycoprotein disrupts flagellum-cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Characterization of the Trypanosoma brucei homologue of a Trypanosoma cruzi flagellum-adhesion glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Analysis of nucleotide sugars from cell lysates by ion-pair solid-phase extraction and reversed-phase high-performance liquid chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Deletion of the GPIdeAc gene alters the location and fate of glycosylphosphatidylinositol precursors in Trypanosoma brucei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Cloning and functional expression of a novel GDP-6-deoxy-D-talose synthetase from Actinobacillus actinomycetemcomitans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Paramecium bursaria Chlorella virus 1 encodes two enzymes involved in the biosynthesis of GDP-L-fucose and GDP-D-rhamnose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Carbohydrate antigens expressed on stem cells and early embryonic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Conditional control of selectin ligand expression and global fucosylation events in mice with a targeted mutation at the FX locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Probing the role of compartmentation of glycolysis in procyclic form Trypanosoma brucei: RNA interference studies of PEX14, hexokinase, and phosphofructokinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Structural characterization of novel oligosaccharides of cell-surface glycoproteins of Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

The flagellar attachment zone of Trypanosoma cruzi epimastigote forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

Comparative compositions of cell surface glycoconjugates isolated from Trypanosoma cruzi epimastigotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

In silico prediction of the glycosomal enzymes of Leishmania major and trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M704742200

21 January 2018

Identifiers

DOI

10.1074/JBC.M704742200

1 reference

24 December 2017

1 reference

24 December 2017