(Q46681211)

24 December 2017

title

Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity (English)

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24 December 2017

author name string

Y Xiao

1

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24 December 2017

M Ge

2

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24 December 2017

X Xue

3

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24 December 2017

C Wang

4

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24 December 2017

H Wang

5

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24 December 2017

X Wu

6

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24 December 2017

L Li

7

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24 December 2017

L Liu

8

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24 December 2017

X Qi

9

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24 December 2017

Y Zhang

10

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24 December 2017

Y Li

11

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24 December 2017

H Luo

12

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24 December 2017

T Xie

13

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24 December 2017

J Gu

14

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24 December 2017

J Ren

15

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24 December 2017

language of work or name

English

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publication date

26 March 2008

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24 December 2017

published in

Kidney International

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24 December 2017

volume

73

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24 December 2017

issue

11

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24 December 2017

page(s)

1231-1239

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24 December 2017

Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs

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For patients taking herbal therapy--lessons from aristolochic acid nephropathy

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Aristolochic acid as a probable human cancer hazard in herbal remedies: a review.

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Balkan endemic nephropathy and associated urinary tract tumours: a review on aetiological causes and the potential role of mycotoxins

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Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?

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7 January 2021

Identification of aristolochic acid in Chinese herbs.

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7 January 2021

Aristolochic acid and the etiology of endemic (Balkan) nephropathy

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7 January 2021

[On the investigation of basic constituents of Achillea species]

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Structure activity relationships of aristolochic acid analogues: toxicity in cultured renal epithelial cells

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7 January 2021

Naturally occurring aristolactams, aristolochic acids and dioxoaporphines and their biological activities

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7 January 2021

Studies on the metabolism of aristolochic acids I and II.

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7 January 2021

Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2

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7 January 2021

Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.

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7 January 2021

Evidence for reductive activation of carcinogenic aristolochic acids by prostaglandin H synthase -- (32)P-postlabeling analysis of DNA adduct formation

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7 January 2021

Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase.

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7 January 2021

The role of cytochrome P450 in cytotoxic bioactivation: future therapeutic directions

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7 January 2021

Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

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7 January 2021

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

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7 January 2021

Mechanism of chloroform-induced renal toxicity: non-involvement of hepatic cytochrome P450-dependent metabolism

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7 January 2021

The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity

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7 January 2021

Role of hepatic cytochrome p450s in the pharmacokinetics and toxicity of cyclophosphamide: studies with the hepatic cytochrome p450 reductase null mouse

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7 January 2021

In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa

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7 January 2021

Induction of Two Forms of Eel Cytochrome P450 1A Genes by 3-Methylcholanthrene

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7 January 2021

The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen

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https://api.crossref.org/works/10.1038%2FKI.2008.103

7 January 2021

Conditional deletion of cytochrome P450 oxidoreductase in the liver and gastrointestinal tract: a new model for studying the functions of the P450 system

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https://api.crossref.org/works/10.1038%2FKI.2008.103

7 January 2021

Study of the phase I and phase II metabolism of nephrotoxin aristolochic acid by liquid chromatography/tandem mass spectrometry

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https://api.crossref.org/works/10.1038%2FKI.2008.103

7 January 2021

Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.103

7 January 2021

Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype

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https://api.crossref.org/works/10.1038%2FKI.2008.103

7 January 2021

Identification and mutagenicity of metabolites of aristolochic acid formed by rat liver.

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https://api.crossref.org/works/10.1038%2FKI.2008.103

7 January 2021

Role of mitochondrial permeability transition in human renal tubular epithelial cell death induced by aristolochic acid.

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https://api.crossref.org/works/10.1038%2FKI.2008.103

7 January 2021

Invasive urothelial carcinoma after exposure to Chinese herbal medicine containing aristolochic acid may occur without severe renal failure.

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7 January 2021

Genetic polymorphisms in human xenobiotica metabolizing enzymes as susceptibility factors in toxic response

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7 January 2021

Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity.

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https://api.crossref.org/works/10.1038%2FKI.2008.103

7 January 2021

Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.103

7 January 2021

Pharmacokinetics and nephrotoxicity of aristolochic acid in rabbits

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.103

7 January 2021

Characterization and determination of six aristolochic acids and three aristololactams in medicinal plants and their preparations by high-performance liquid chromatography-photodiode array detection/electrospray ionization mass spectrometry.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.103

7 January 2021

Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.

1 reference

https://api.crossref.org/works/10.1038%2FKI.2008.103

7 January 2021

Identifiers

DOI

10.1038/KI.2008.103

1 reference

24 December 2017

1 reference

24 December 2017