(Q38520051)

English

Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype

scientific article published on 08 July 2005

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Europe PubMed Central

PubMed publication ID

3 September 2017

Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

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Paul N Black

4

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author name string

Yan Weng

1

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

Concetta C DiRusso

2

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

Andrew A Reilly

3

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

Xinxin Ding

5

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Europe PubMed Central

PubMed publication ID

3 September 2017

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publication date

8 July 2005

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Europe PubMed Central

PubMed publication ID

3 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

3 September 2017

280

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Europe PubMed Central

PubMed publication ID

3 September 2017

36

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

31686-31698

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

Evidence for requirement of NADPH-cytochrome P450 oxidoreductase in the microsomal NADPH-sterol Delta7-reductase system

1 reference

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21 January 2018

The roles of cytochrome b5 in cytochrome P450 reactions

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21 January 2018

Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase

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21 January 2018

Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis

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21 January 2018

Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome

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21 January 2018

Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene.

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21 January 2018

Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

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21 January 2018

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

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21 January 2018

Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450

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Fatty acid transport in Saccharomyces cerevisiae. Directed mutagenesis of FAT1 distinguishes the biochemical activities associated with Fat1p

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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

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A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism.

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Recent advances in the study of fatty acid desaturases from animals and lower eukaryotes

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Effect of the delta6-desaturase inhibitor SC-26196 on PUFA metabolism in human cells

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Metabolism of highly unsaturated n-3 and n-6 fatty acids

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21 January 2018

The cytochrome P450 4 (CYP4) family

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21 January 2018

Ablation of the Liver Fatty Acid Binding Protein Gene Decreases Fatty Acyl CoA Binding Capacity and Alters Fatty Acyl CoA Pool Distribution in Mouse Liver

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21 January 2018

Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane

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21 January 2018

Bile acid regulation of gene expression: roles of nuclear hormone receptors.

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21 January 2018

The enzymes, regulation, and genetics of bile acid synthesis

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21 January 2018

Structure, evolution, and liver-specific expression of sterol 12alpha-hydroxylase P450 (CYP8B)

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21 January 2018

Structure of the rat gene encoding cholesterol 7 alpha-hydroxylase

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21 January 2018

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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21 January 2018

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

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21 January 2018

Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

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21 January 2018

The role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor activator that can act as a suppressor of bile acid biosynthesis

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21 January 2018

Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein.

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21 January 2018

Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion

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21 January 2018

Bile salt transporters

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21 January 2018

Peroxisome proliferator-activated receptors: nuclear control of metabolism

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21 January 2018

Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)

1 reference

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21 January 2018

Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.

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21 January 2018

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

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Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor

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Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter

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Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression

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Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2

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P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

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Squalestatin 1-inducible expression of rat CYP2B: evidence that an endogenous isoprenoid is an activator of the constitutive androstane receptor

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Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

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Humanized xenobiotic response in mice expressing nuclear receptor SXR.

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In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa

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Gene expression changes associated with the endoplasmic reticulum stress response induced by microsomal cytochrome p450 overproduction

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Diversity and function of mutations in p450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis

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21 January 2018

Identifiers

10.1074/JBC.M504447200

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

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