(Q46700264)

24 December 2017

title

Structure-based virtual screening against SARS-3CL(pro) to identify novel non-peptidic hits (English)

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24 December 2017

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Prasenjit Mukherjee

1

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24 December 2017

Prashant Desai

2

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24 December 2017

Larry Ross

3

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24 December 2017

E Lucile White

4

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24 December 2017

Mitchell A Avery

5

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24 December 2017

language of work or name

English

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publication date

11 January 2008

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24 December 2017

Bioorganic & Medicinal Chemistry

published in

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24 December 2017

volume

16

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24 December 2017

issue

7

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24 December 2017

page(s)

4138-4149

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24 December 2017

Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations

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3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanism

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12 December 2020

High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase

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12 December 2020

Crystal structures reveal an induced-fit binding of a substrate-like Aza-peptide epoxide to SARS coronavirus main peptidase

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Quaternary structure, substrate selectivity and inhibitor design for SARS 3C-like proteinase

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Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme: defining the extra domain as a new target for design of highly specific protease inhibitors

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Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease.

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A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase

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Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors

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An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors

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Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors

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Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro

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Discovering severe acute respiratory syndrome coronavirus 3CL protease inhibitors: virtual screening, surface plasmon resonance, and fluorescence resonance energy transfer assays

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Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro

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12 December 2020

10.1016/J.BMC.2008.01.011

Identifiers

DOI

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24 December 2017

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24 December 2017