(Q46715801)

English

The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: a possible mechanism for clopidogrel resistance

scientific article published on 5 March 2008

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scholarly article

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18323861

The effect of CYP2C19 polymorphism on the pharmacokinetics and pharmacodynamics of clopidogrel: a possible mechanism for clopidogrel resistance (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18323861

1 reference

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inferred from title

pharmacokinetics

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pharmacodynamics

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author name string

K A Kim

1

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18323861

P W Park

2

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18323861

S J Hong

3

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18323861

J-Y Park

4

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18323861

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publication date

5 March 2008

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18323861

number of pages

7

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Clinical Pharmacology & Therapeutics

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18323861

84

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18323861

2

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18323861

236-242

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18323861

Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel

1 reference

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Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity

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Durability of platelet inhibition by clopidogrel

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7 January 2021

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Resistance to clopidogrel: a review of the evidence

1 reference

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Aspirin and clopidogrel resistance

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Structure and stereochemistry of the active metabolite of clopidogrel

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P2y(12), a new platelet ADP receptor, target of clopidogrel

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7 January 2021

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Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance

1 reference

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7 January 2021

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Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects

1 reference

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Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel

1 reference

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7 January 2021

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Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects

1 reference

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Cytochrome P450 2C19 loss-of-function polymorphism, but not CYP3A4 IVS10 + 12G/A and P2Y12 T744C polymorphisms, is associated with response variability to dual antiplatelet treatment in high-risk vascular patients.

1 reference

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Clinical significance of the cytochrome P450 2C19 genetic polymorphism

1 reference

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7 January 2021

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inferred from DOI database lookup

Aspirin and clopidogrel resistance: an emerging clinical entity

1 reference

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7 January 2021

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Possible mechanisms of drug-induced aspirin and clopidogrel resistance

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Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently

1 reference

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7 January 2021

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Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction

1 reference

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7 January 2021

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The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin

1 reference

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7 January 2021

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Biological effect of increased maintenance dose of clopidogrel in cardiovascular outpatients and influence of the cytochrome P450 2C19*2 allele on clopidogrel responsiveness

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7 January 2021

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Enantioselective disposition of lansoprazole in extensive and poor metabolizers of CYP2C19.

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7 January 2021

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CYP2C19‐ and CYP3A4‐Dependent Omeprazole Metabolism in West Mexicans

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7 January 2021

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Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin

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7 January 2021

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Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: a systematic review and meta-analysis.

1 reference

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7 January 2021

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Clopidogrel poor responders: an objective definition based on Bayesian classification

1 reference

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7 January 2021

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Drug interactions and the cytochrome P450 system. The role of cytochrome P450 2C19.

1 reference

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7 January 2021

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Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement

1 reference

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7 January 2021

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High clopidogrel loading dose during coronary stenting: effects on drug response and interindividual variability.

1 reference

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7 January 2021

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Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy.

1 reference

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7 January 2021

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Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans

1 reference

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7 January 2021

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Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting.

1 reference

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7 January 2021

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807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment

1 reference

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7 January 2021

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Reliability of the omeprazole hydroxylation index for CYP2C19 phenotyping: possible effect of age, liver disease and length of therapy

1 reference

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The effect of the CYP2C19 genotype on the hydroxylation index of omeprazole in South Indians

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Identifiers

10.1038/CLPT.2008.20

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18323861

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/18323861

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