(Q46717211)

English

Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis

scientific article published in October 2005

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scholarly article

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/16180087

Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis (English)

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/16180087

transmembrane protein

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1 reference

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inferred from title

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author name string

Jennifer Y Kong

1

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/16180087

Shaun S Klassen

2

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/16180087

Simon W Rabkin

3

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/16180087

publication date

1 October 2005

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/16180087

Molecular and Cellular Biochemistry

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/16180087

278

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Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/16180087

39-51

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Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/16180087

1-2

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Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/16180087

https://scigraph.springernature.com/pub.10.1007/s11010-005-1979-6

0 references

Ceramide in apoptosis: an overview and current perspectives

1 reference

https://api.crossref.org/works/10.1007%2FS11010-005-1979-6

21 January 2018

B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway

1 reference

https://api.crossref.org/works/10.1007%2FS11010-005-1979-6

21 January 2018

Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion

1 reference

https://api.crossref.org/works/10.1007%2FS11010-005-1979-6

21 January 2018

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

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https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Adenosine-induced late preconditioning in mouse hearts: role of p38 MAP kinase and mitochondrial K(ATP) channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Centrifugation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of fluorescent dyes for the detection of mitochondrial membrane potential changes in cultured cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondria control of cell death induced by anti-HLA-DR antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha mediated activation of signal transduction cascades and transcription factors in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of angiotensin II-induced activation of mitogen-activated protein kinase in cardiac hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breaking the mitochondrial barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of caspase 3- and 8-like proteases in ceramide-induced apoptosis of cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New advances on structural and biological functions of ceramide in apoptotic/necrotic cell death and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in myocardial ischemia-reperfusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Capsaicin-induced depolarisation of mitochondria in dorsal root ganglion neurons is enhanced by vanilloid receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dual function for p38 MAP kinase in hematopoietic cells: involvement in apoptosis and cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Initiator caspases in apoptosis signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lovastatin does not accentuate but is rather additive to palmitate-induced apoptosis in cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Real-time single cell analysis of Smac/DIABLO release during apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of p38 mitogen-activated protein kinase and mitochondrial Ca(2+)-mediated oxidative stress are essential for the enhanced expression of grp78 induced by the protein phosphatase inhibitors okadaic acid and calyculin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Features of apoptotic cells measured by flow cytometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial transport of cations: channels, exchangers, and permeability transition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial targeting of JNK/SAPK in the phorbol ester response of myeloid leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitroprusside induces cardiomyocyte death: interaction with hydrogen peroxide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine/threonine protein kinases and apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct regulation of osmoprotective genes in yeast and mammals. Aldose reductase osmotic response element is induced independent of p38 and stress-activated protein kinase/Jun N-terminal kinase in rabbit kidney cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitochondrial permeability transition pore and its role in cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: prevention by cyclosporin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial intermembrane proteins in cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Apoptosis and necrosis in health and disease: Role of mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Thapsigargin enhances camptothecin-induced apoptosis in cardiomyocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11010-005-1979-6

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/16180087

1 reference

Europe PubMed Central

24 December 2017

http://europepmc.org/abstract/MED/16180087

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