(Q46717211)

English

Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis

scientific article published in October 2005

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/16180087

Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/16180087

transmembrane protein

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author name string

Jennifer Y Kong

1

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/16180087

Shaun S Klassen

2

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/16180087

Simon W Rabkin

3

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/16180087

publication date

1 October 2005

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/16180087

Molecular and Cellular Biochemistry

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/16180087

278

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/16180087

1-2

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/16180087

39-51

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/16180087

Ceramide in apoptosis: an overview and current perspectives

1 reference

https://api.crossref.org/works/10.1007%2FS11010-005-1979-6

21 January 2018

B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway

1 reference

https://api.crossref.org/works/10.1007%2FS11010-005-1979-6

21 January 2018

Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion

1 reference

https://api.crossref.org/works/10.1007%2FS11010-005-1979-6

21 January 2018

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

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https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

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https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation

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https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection

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https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Adenosine-induced late preconditioning in mouse hearts: role of p38 MAP kinase and mitochondrial K(ATP) channels

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https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide

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https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit

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https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Centrifugation.

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https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Evaluation of fluorescent dyes for the detection of mitochondrial membrane potential changes in cultured cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Mitochondria control of cell death induced by anti-HLA-DR antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Tumor necrosis factor-alpha mediated activation of signal transduction cascades and transcription factors in 3T3-L1 adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of p38 mitogen-activated protein kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Reduction of angiotensin II-induced activation of mitogen-activated protein kinase in cardiac hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Breaking the mitochondrial barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Involvement of caspase 3- and 8-like proteases in ceramide-induced apoptosis of cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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New advances on structural and biological functions of ceramide in apoptotic/necrotic cell death and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Commitment to apoptosis by ceramides depends on mitochondrial respiratory function, cytochrome c release and caspase-3 activation in Hep-G2 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Apoptosis in myocardial ischemia-reperfusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Capsaicin-induced depolarisation of mitochondria in dorsal root ganglion neurons is enhanced by vanilloid receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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One-way cross-talk between p38(MAPK) and p42/44(MAPK). Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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A dual function for p38 MAP kinase in hematopoietic cells: involvement in apoptosis and cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Initiator caspases in apoptosis signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Mitochondrial effects with ceramide-induced cardiac apoptosis are different from those of palmitate

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Lovastatin does not accentuate but is rather additive to palmitate-induced apoptosis in cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Real-time single cell analysis of Smac/DIABLO release during apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Activation of p38 mitogen-activated protein kinase and mitochondrial Ca(2+)-mediated oxidative stress are essential for the enhanced expression of grp78 induced by the protein phosphatase inhibitors okadaic acid and calyculin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Features of apoptotic cells measured by flow cytometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial transport of cations: channels, exchangers, and permeability transition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial targeting of JNK/SAPK in the phorbol ester response of myeloid leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitroprusside induces cardiomyocyte death: interaction with hydrogen peroxide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Serine/threonine protein kinases and apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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inferred from PubMed ID database lookup

Mitochondrial translocation of protein kinase C delta in phorbol ester-induced cytochrome c release and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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inferred from PubMed ID database lookup

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Distinct regulation of osmoprotective genes in yeast and mammals. Aldose reductase osmotic response element is induced independent of p38 and stress-activated protein kinase/Jun N-terminal kinase in rabbit kidney cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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The mitochondrial permeability transition pore and its role in cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: prevention by cyclosporin A

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Mitochondrial intermembrane proteins in cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Apoptosis and necrosis in health and disease: Role of mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

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Thapsigargin enhances camptothecin-induced apoptosis in cardiomyocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

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Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16180087

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11010-005-1979-6

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/16180087

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/16180087

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