(Q34975049)

5 August 2017

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title

New advances on structural and biological functions of ceramide in apoptotic/necrotic cell death and cancer (English)

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5 August 2017

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Murielle Mimeault

1

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5 August 2017

language of work or name

English

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publication date

1 October 2002

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5 August 2017

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5 August 2017

volume

530

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5 August 2017

issue

1-3

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5 August 2017

page(s)

9-16

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Ceramide in the eukaryotic stress response

5 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide induces cell death in the human prostatic carcinoma cell lines PC3 and DU145 but does not seem to be involved in Fas-mediated apoptosis.

21 January 2018

1 reference

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Ceramide-induced cell death in the prostate cancer cell line LNCaP has both necrotic and apoptotic features

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide: a new second messenger of cannabinoid action

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Sphingolipid transport: rafts and translocators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide inactivates cellular protein kinase Calpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Alteration of the sphingomyelin/ceramide pathway is associated with resistance of human breast carcinoma MCF7 cells to tumor necrosis factor-alpha-mediated cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Down-regulation of ceramide production abrogates ionizing radiation-induced cytochrome c release and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Distinct effects of ceramide-generating pathways in prostate adenocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Subtype-specific translocation of the delta subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Permeability barrier disorder in Niemann-Pick disease: sphingomyelin-ceramide processing required for normal barrier homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

FTIR spectroscopic analyses of the temperature and pH influences on stratum corneum lipid phase behaviors and interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Priming prostate carcinoma cells for increased apoptosis is associated with up-regulation of the caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Sphingosine kinase: a mediator of vital cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Molecular cloning and characterization of a human mitochondrial ceramidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Sphingomyelin and derivatives as cellular signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Structure and function of sphingolipid- and cholesterol-rich membrane rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Signalling and non-caveolar rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Calcium-independent activation of endothelial nitric oxide synthase by ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Cathepsin D targeted by acid sphingomyelinase-derived ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Mitochondria as the central control point of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Mitochondria: execution central

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

A structural view of mitochondria-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Bcl-2 family proteins as ion-channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide in apoptosis--does it really matter?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide regulates cellular homeostasis via diverse stress signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Bcl-2 phosphorylation required for anti-apoptosis function

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide induces caspase-independent apoptosis in rat hepatocytes sensitized by inhibition of RNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

The acid sphingomyelinase inhibitor SR33557 counteracts TNF-alpha-mediated potentiation of IL-1beta-induced NF-kappaB activation in the insulin-producing cell line Rinm5F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Nitric oxide induces apoptosis via triggering mitochondrial permeability transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Cross-talk between nitric oxide and superoxide determines ceramide formation and apoptosis in glomerular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Interactions of nitric oxide-derived reactive nitrogen species with peroxidases and lipoxygenases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Human acid ceramidase is overexpressed but not mutated in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Segregation of Bad from lipid rafts is implicated in the induction of apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, a

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Interaction of cholesterol with various glycerophospholipids and sphingomyelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Heterologous desensitization of EGF receptors and PDGF receptors by sequestration in caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Cholesterol depletion inhibits epidermal growth factor receptor transactivation by angiotensin II in vascular smooth muscle cells: role of cholesterol-rich microdomains and focal adhesions in angiotensin II signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain: potential implications in tumour necrosis factor signalling

21 January 2018

2 references

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

21 January 2018

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

inferred from DOI database lookup

7 January 2021

based on heuristic

CD95 Signaling via Ceramide-rich Membrane Rafts

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Induction of apoptotic DNA fragmentation and cell death by natural ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide induces aSMase expression: implications for oxLDL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Potential target found for antimetastasis drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Compartmentalized Production of Ceramide at the Cell Surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide-rich membrane rafts mediate CD40 clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide activates the stress-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Fumonisin B1 does not prevent apoptosis in A431 human epidermoid carcinoma cells after photosensitization with a silicon phthalocyanine

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Natural ceramide is unable to escape the lysosome, in contrast to a fluorescent analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Apoptosis. Mitochondria--the death signal integrators

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Nitric oxide stimulates chronic ceramide formation in glomerular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Identification of soluble protein phosphatases that dephosphorylate voltage-sensitive sodium channels in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Alterations to glutathione and nicotinamide nucleotides during the mitochondrial permeability transition induced by peroxynitrite

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

Positive feedback control of neutral sphingomyelinase activity by ceramide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2802%2903432-4

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0014-5793(02)03432-4

1 reference

5 August 2017

1 reference