(Q46722763)

24 December 2017

title

Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein (English)

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24 December 2017

main subject

transmembrane protein

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Heather Sadlish

1

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24 December 2017

David Pitonzo

series ordinal

2

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24 December 2017

Arthur E Johnson

series ordinal

3

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24 December 2017

William R Skach

series ordinal

4

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24 December 2017

publication date

25 September 2005

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24 December 2017

Nature Structural & Molecular Biology

published in

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24 December 2017

volume

12

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24 December 2017

issue

10

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24 December 2017

page(s)

870-878

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24 December 2017

https://scigraph.springernature.com/pub.10.1038/nsmb994

exact match

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cites work

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Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore.

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A nascent membrane protein is located adjacent to ER membrane proteins throughout its integration and translation

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Cotranslational protein integration into the ER membrane is mediated by the binding of nascent chains to translocon proteins.

21 January 2018

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Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins.

21 January 2018

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Sec61p is adjacent to nascent type I and type II signal-anchor proteins during their membrane insertion.

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1 reference

The protein-conducting channel in the membrane of the endoplasmic reticulum is open laterally toward the lipid bilayer.

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21 January 2018

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1 reference

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21 January 2018

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21 January 2018

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The cotranslational integration of membrane proteins into the phospholipid bilayer is a multistep process

31 March 2020

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Molecular mechanism of membrane protein integration into the endoplasmic reticulum

31 March 2020

1 reference

The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain

31 March 2020

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A novel integration signal that is composed of two transmembrane segments is required to integrate the Neurospora plasma membrane H(+)-ATPase into microsomes

31 March 2020

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Biogenesis of Polytopic Membrane Proteins: Membrane Segments of P-glycoprotein Sequentially Translocate To Span the ER Membrane†

31 March 2020

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31 March 2020

1 reference

The aqueous pore through the translocon has a diameter of 40-60 A during cotranslational protein translocation at the ER membrane

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB994

1 reference

24 December 2017

1 reference

24 December 2017