(Q46748108)

24 December 2017

title

Conjugation of LG domains of agrins and perlecan to polymerizing laminin-2 promotes acetylcholine receptor clustering (English)

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24 December 2017

author name string

Sergei P Smirnov

1

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24 December 2017

Patrizia Barzaghi

2

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24 December 2017

Karen K McKee

3

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24 December 2017

Markus A Ruegg

4

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24 December 2017

Peter D Yurchenco

5

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24 December 2017

language of work or name

English

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publication date

11 October 2005

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24 December 2017

Journal of Biological Chemistry

published in

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24 December 2017

volume

280

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24 December 2017

issue

50

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24 December 2017

page(s)

41449-41457

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24 December 2017

The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin

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Structure of the C-terminal laminin G-like domain pair of the laminin alpha2 chain harbouring binding sites for alpha-dystroglycan and heparin

21 January 2018

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The basement membrane/basal lamina of skeletal muscle

21 January 2018

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Basement membrane assembly, stability and activities observed through a developmental lens.

21 January 2018

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Laminin-sulfatide binding initiates basement membrane assembly and enables receptor signaling in Schwann cells and fibroblasts

21 January 2018

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Laminin-induced acetylcholine receptor clustering: an alternative pathway

21 January 2018

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Contributions of the LG modules and furin processing to laminin-2 functions

21 January 2018

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Laminin-1 redistributes postsynaptic proteins and requires rapsyn, tyrosine phosphorylation, and Src and Fyn to stably cluster acetylcholine receptors

21 January 2018

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Nerve-independent formation of a topologically complex postsynaptic apparatus.

21 January 2018

1 reference

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Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site

21 January 2018

1 reference

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An alternative amino-terminus expressed in the central nervous system converts agrin to a type II transmembrane protein.

21 January 2018

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Agrin binds to the nerve-muscle basal lamina via laminin

21 January 2018

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Interaction of agrin with laminin requires a coiled-coil conformation of the agrin-binding site within the laminin gamma1 chain

21 January 2018

1 reference

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Mapping of the laminin-binding site of the N-terminal agrin domain (NtA).

21 January 2018

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Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse

21 January 2018

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New insights into the roles of agrin

21 January 2018

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Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin.

21 January 2018

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Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins

21 January 2018

1 reference

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Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan

21 January 2018

1 reference

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The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans

21 January 2018

1 reference

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Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice

21 January 2018

1 reference

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A simplified laminin nomenclature

21 January 2018

1 reference

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A minigene of neural agrin encoding the laminin-binding and acetylcholine receptor-aggregating domains is sufficient to induce postsynaptic differentiation in muscle fibres

21 January 2018

1 reference

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An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy.

21 January 2018

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Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction

21 January 2018

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The postsynaptic submembrane machinery at the neuromuscular junction: requirement for rapsyn and the utrophin/dystrophin-associated complex.

21 January 2018

1 reference

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Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development

21 January 2018

1 reference

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Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation

21 January 2018

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Absence of basement membranes after targeting the LAMC1 gene results in embryonic lethality due to failure of endoderm differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508939200

The dystroglycan complex is necessary for stabilization of acetylcholine receptor clusters at neuromuscular junctions and formation of the synaptic basement membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508939200

Laminin polymerization induces a receptor-cytoskeleton network

21 January 2018

1 reference

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Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands

21 January 2018

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Substrate compliance versus ligand density in cell on gel responses

21 January 2018

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Molecular dissection of neuromuscular junction formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508939200

A functional role for specific spliced variants of the alpha7beta1 integrin in acetylcholine receptor clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508939200

Development of the vertebrate neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508939200

Alternative splicing of agrin alters its binding to heparin, dystroglycan, and the putative agrin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M508939200

21 January 2018

Identifiers

DOI

10.1074/JBC.M508939200

1 reference

24 December 2017

PubMed ID

16219760

1 reference

24 December 2017