(Q35097331)

6 August 2017

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title

New insights into the roles of agrin (English)

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6 August 2017

Gabriela Bezakova

1

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PubMed ID

12671652

6 August 2017

Markus A Ruegg

series ordinal

2

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6 August 2017

1 April 2003

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Nature Reviews Molecular Cell Biology

6 August 2017

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6 August 2017

4

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6 August 2017

4

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6 August 2017

295-308

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https://scigraph.springernature.com/pub.10.1038/nrm1074

6 August 2017

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cites work

Lymphocyte responses and cytokines

1 reference

Molecules, maps and synapse specificity.

31 March 2020

1 reference

Induction, assembly, maturation and maintenance of a postsynaptic apparatus

31 March 2020

1 reference

Signaling takes shape in the immune system

31 March 2020

1 reference

Agrin orchestrates synaptic differentiation at the vertebrate neuromuscular junction

31 March 2020

1 reference

Physiological regulation of the immunological synapse by agrin

31 March 2020

1 reference

Muscle activity and muscle agrin regulate the organization of cytoskeletal proteins and attached acetylcholine receptor (AchR) aggregates in skeletal muscle fibers

31 March 2020

1 reference

An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy.

31 March 2020

1 reference

Reinnervation of muscle fiber basal lamina after removal of myofibers. Differentiation of regenerating axons at original synaptic sites

31 March 2020

1 reference

Acetylcholine receptors in regenerating muscle accumulate at original synaptic sites in the absence of the nerve

31 March 2020

1 reference

Identification of agrin, a synaptic organizing protein from Torpedo electric organ

31 March 2020

1 reference

31 March 2020

1 reference

Defective neuromuscular synaptogenesis in agrin-deficient mutant mice

31 March 2020

1 reference

Induction by agrin of ectopic and functional postsynaptic-like membrane in innervated muscle

31 March 2020

1 reference

Effects of purified recombinant neural and muscle agrin on skeletal muscle fibers in vivo.

31 March 2020

1 reference

Agrin is a heparan sulfate proteoglycan

31 March 2020

1 reference

Structure and expression of a rat agrin

31 March 2020

1 reference

cDNA that encodes active agrin

31 March 2020

1 reference

An amino-terminal extension is required for the secretion of chick agrin and its binding to extracellular matrix

31 March 2020

1 reference

An alternative amino-terminus expressed in the central nervous system converts agrin to a type II transmembrane protein.

31 March 2020

1 reference

Agrin binds to the nerve-muscle basal lamina via laminin

31 March 2020

1 reference

Alternative splicing of agrin alters its binding to heparin, dystroglycan, and the putative agrin receptor

31 March 2020

1 reference

A capacitative calcium current in cultured skeletal muscle cells is mediated by the calcium-specific leak channel and inhibited by dihydropyridine compounds

31 March 2020

1 reference

Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction

31 March 2020

1 reference

Schwann cells express active agrin and enhance aggregation of acetylcholine receptors on muscle fibers.

31 March 2020

1 reference

Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site

31 March 2020

1 reference

Development of the vertebrate neuromuscular junction

31 March 2020

1 reference

Identification and purification of an agrin receptor from Torpedo postsynaptic membranes: a heteromeric complex related to the dystroglycans

31 March 2020

1 reference

Dystroglycan-alpha, a dystrophin-associated glycoprotein, is a functional agrin receptor

31 March 2020

1 reference

A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering

31 March 2020

1 reference

Dystroglycan binds nerve and muscle agrin

31 March 2020

1 reference

Chimaeric mice deficient in dystroglycans develop muscular dystrophy and have disrupted myoneural synapses

31 March 2020

1 reference

Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex

31 March 2020

1 reference

The dystroglycan complex is necessary for stabilization of acetylcholine receptor clusters at neuromuscular junctions and formation of the synaptic basement membrane

31 March 2020

1 reference

The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo

31 March 2020

1 reference

Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor.

31 March 2020

1 reference

Agrin acts via a MuSK receptor complex

31 March 2020

1 reference

Agrin in the CNS: a protein in search of a function?

31 March 2020

1 reference

Agrin plays an organizing role in the formation of sympathetic synapses

31 March 2020

1 reference

Expression and localization of agrin during sympathetic synapse formation in vitro

31 March 2020

1 reference

Cloning and characterization of muscle-specific kinase in chicken.

31 March 2020

1 reference

Agrin controls synaptic differentiation in hippocampal neurons.

31 March 2020

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Specific agrin isoforms induce cAMP response element binding protein phosphorylation in hippocampal neurons.

31 March 2020

1 reference

Agrin is a differentiation-inducing "stop signal" for motoneurons in vitro

31 March 2020

1 reference

Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain

31 March 2020

1 reference

Agrin in Alzheimer's disease: altered solubility and abnormal distribution within microvasculature and brain parenchyma

31 March 2020

1 reference

Synapse formation by hippocampal neurons from agrin-deficient mice

31 March 2020

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Formation of functional synaptic connections between cultured cortical neurons from agrin-deficient mice

31 March 2020

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The agrin gene codes for a family of basal lamina proteins that differ in function and distribution

31 March 2020

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Structural domains of agrin required for clustering of nicotinic acetylcholine receptors.

31 March 2020

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Role for a synapse-specific carbohydrate in agrin-induced clustering of acetylcholine receptors

31 March 2020

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Agrin-independent activation of the agrin signal transduction pathway

31 March 2020

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Sialic acid inhibits agrin signaling in C2 myotubes

31 March 2020

1 reference

Modulation of agrin binding and activity by the CT and related carbohydrate antigens

31 March 2020

1 reference

Overexpression of the CT GalNAc transferase in skeletal muscle alters myofiber growth, neuromuscular structure, and laminin expression.

31 March 2020

1 reference

Embryonic growth and innervation of rat skeletal muscles. - III. Neural regulation of junctional and extra-junctional acetylcholine receptor clusters

31 March 2020

1 reference

DNA topoisomerase IIbeta and neural development

31 March 2020

1 reference

Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse

31 March 2020

1 reference

Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation

31 March 2020

1 reference

Targeting transcription to the neuromuscular synapse

31 March 2020

1 reference

The distribution of acetylcholine sensitivity over uninnervated and innervated muscle fibers grown in cell culture

31 March 2020

1 reference

Multiple regulatory events controlling the expression and localization of utrophin in skeletal muscle fibers: insights into a therapeutic strategy for Duchenne muscular dystrophy

31 March 2020

1 reference

The actin-driven movement and formation of acetylcholine receptor clusters

31 March 2020

1 reference

Agrin-induced acetylcholine receptor clustering is mediated by the small guanosine triphosphatases Rac and Cdc42

31 March 2020

1 reference

Synapse-forming axons and recombinant agrin induce microprocess formation on myotubes

31 March 2020

1 reference

Agrin induces phosphorylation of the nicotinic acetylcholine receptor

31 March 2020

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Recruitment of a nicotinic acetylcholine receptor mutant lacking cytoplasmic tyrosine residues in its beta subunit into agrin-induced aggregates

31 March 2020

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Agrin-induced acetylcholine receptor clustering in mammalian muscle requires tyrosine phosphorylation

31 March 2020

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Agrin-induced phosphorylation of the acetylcholine receptor regulates cytoskeletal anchoring and clustering

31 March 2020

1 reference

Phosphorylation and cytoskeletal anchoring of the acetylcholine receptor by Src class protein-tyrosine kinases. Activation by rapsyn

31 March 2020

1 reference

Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1

31 March 2020

1 reference

Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex

31 March 2020

1 reference

The promise and perils of Wnt signaling through beta-catenin.

31 March 2020

1 reference

Association of cortactin with developing neuromuscular specializations

31 March 2020

1 reference

Antigen-receptor induced clonal expansion and deletion of lymphocytes are impaired in mice lacking HS1 protein, a substrate of the antigen-receptor-coupled tyrosine kinases.

31 March 2020

1 reference

Cortactin: coupling membrane dynamics to cortical actin assembly

31 March 2020

1 reference

Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue

31 March 2020

1 reference

Mapping sites responsible for interactions of agrin with neurons.

31 March 2020

1 reference

Supramolecular organization of the subsarcolemmal cytoskeleton of adult skeletal muscle fibers. A review

31 March 2020

1 reference

Form and function: the laminin family of heterotrimers

31 March 2020

1 reference

Muscular dystrophies involving the dystrophin-glycoprotein complex: an overview of current mouse models.

31 March 2020

1 reference

Extensive but coordinated reorganization of the membrane skeleton in myofibers of dystrophic (mdx) mice

31 March 2020

1 reference

Assembly and mechanosensory function of focal contacts

31 March 2020

1 reference

Exploring the neighborhood: adhesion-coupled cell mechanosensors.

31 March 2020

1 reference

Inhibition of myosin light chain kinase by p21-activated kinase

31 March 2020

1 reference

Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading

31 March 2020

1 reference

Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors.

31 March 2020

1 reference

The Ets transcription factor GABP is required for postsynaptic differentiation in vivo.

31 March 2020

1 reference

Intracellular calcium regulates agrin-induced acetylcholine receptor clustering

31 March 2020

1 reference

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

31 March 2020

1 reference

CD44: from adhesion molecules to signalling regulators

31 March 2020

1 reference

The two poles of the lymphocyte: specialized cell compartments for migration and recruitment

31 March 2020

1 reference

Glycosylation of CD44 negatively regulates its recognition of hyaluronan

31 March 2020

1 reference

Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice.

31 March 2020

1 reference

The myristoylated protein rapsyn is cotargeted with the nicotinic acetylcholine receptor to the postsynaptic membrane via the exocytic pathway

31 March 2020

1 reference

Rapsyn escorts the nicotinic acetylcholine receptor along the exocytic pathway via association with lipid rafts

31 March 2020

1 reference

Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold

31 March 2020

1 reference

Agrin-induced activation of acetylcholine receptor-bound Src family kinases requires Rapsyn and correlates with acetylcholine receptor clustering.

31 March 2020

1 reference

Evidence for in situ and in vitro association between beta-dystroglycan and the subsynaptic 43K rapsyn protein. Consequence for acetylcholine receptor clustering at the synapse

31 March 2020

1 reference

Remodeling of synaptic actin induced by photoconductive stimulation

31 March 2020

1 reference

Structure and chromosomal localization of the mammalian agrin gene

31 March 2020

1 reference

The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans

31 March 2020

1 reference

The complexities of dystroglycan

31 March 2020

1 reference

Dystroglycan is essential for early embryonic development: disruption of Reichert's membrane in Dag1-null mice

31 March 2020

1 reference

Post-translational disruption of dystroglycan-ligand interactions in congenital muscular dystrophies

31 March 2020

1 reference

Muscle-specific trk-related receptor with a kringle domain defines a distinct class of receptor tyrosine kinases

31 March 2020

1 reference

Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury

31 March 2020

1 reference

The juxtamembrane region of MuSK has a critical role in agrin-mediated signaling

31 March 2020

1 reference

Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies

31 March 2020

1 reference

Lipid rafts and signal transduction

31 March 2020

1 reference

Spatial distribution and subunit composition of GABA(A) receptors in the inferior olivary nucleus

31 March 2020

1 reference

Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

31 March 2020

1 reference

Distribution of agrin mRNAs in the chick embryo nervous system.

31 March 2020

1 reference

Tissue- and age-specific expression patterns of alternatively spliced agrin mRNA transcripts in embryonic rat suggest novel developmental roles.

31 March 2020

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Developmental regulation of highly active alternatively spliced forms of agrin

31 March 2020

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Agrin mRNA variants are differentially regulated in developing chick embryo spinal cord and sensory ganglia.

31 March 2020

1 reference

Localization and alternative splicing of agrin mRNA in adult rat brain: transcripts encoding isoforms that aggregate acetylcholine receptors are not restricted to cholinergic regions.

31 March 2020

1 reference

Cell-specific regulation of agrin RNA splicing in the chick ciliary ganglion

31 March 2020

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Differential distribution of agrin isoforms in the developing and adult avian retina

31 March 2020

1 reference

Agrin isoforms with distinct amino termini: differential expression, localization, and function

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM1074

1 reference

6 August 2017

1 reference

PubMed ID

12671652