(Q46765399)

25 December 2017

title

Functional selectivity of GPCR-directed drug action through location bias (English)

1 reference

25 December 2017

G protein-coupled receptor

main subject

0 references

1 reference

7

Mark von Zastrow

1 reference

25 December 2017

author name string

Roshanak Irannejad

1

1 reference

25 December 2017

Veronica Pessino

2

1 reference

25 December 2017

Delphine Mika

3

1 reference

25 December 2017

Bo Huang

4

1 reference

25 December 2017

Philip B Wedegaertner

5

1 reference

25 December 2017

Marco Conti

6

1 reference

25 December 2017

publication date

29 May 2017

1 reference

25 December 2017

published in

Nature Chemical Biology

1 reference

25 December 2017

volume

13

1 reference

25 December 2017

issue

7

1 reference

25 December 2017

page(s)

799-806

1 reference

25 December 2017

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5733145/fullTextXML

inferred from PubMed Central ID database lookup

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G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway

24 May 2018

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24 May 2018

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24 May 2018

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24 May 2018

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Gαs regulates the post-endocytic sorting of G protein-coupled receptors

24 May 2018

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Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance

24 May 2018

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24 May 2018

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Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy

24 May 2018

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Conformational biosensors reveal GPCR signalling from endosomes.

24 May 2018

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OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

24 May 2018

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Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex

24 May 2018

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Nanobody stabilization of G protein-coupled receptor conformational states.

24 May 2018

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Isoproterenol cytotoxicity is dependent on the differentiation state of the cardiomyoblast H9c2 cell line

24 May 2018

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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

24 May 2018

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Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits

24 May 2018

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PKA-mediated Golgi remodeling during cAMP signal transmission

24 May 2018

1 reference

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Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.

24 May 2018

1 reference

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Persistent cAMP-signals triggered by internalized G-protein-coupled receptors

24 May 2018

1 reference

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Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes

24 May 2018

1 reference

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Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC.

24 May 2018

1 reference

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The evasive nature of drug efficacy: implications for drug discovery

24 May 2018

1 reference

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Biopharmaceutics classification of selected beta-blockers: solubility and permeability class membership

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

The origins of diversity and specificity in g protein-coupled receptor signaling

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

AKAP signalling complexes: focal points in space and time

24 May 2018

1 reference

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Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells

24 May 2018

1 reference

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Differential subcellular location of mitochondria in rat serotonergic neurons depends on the presence and the absence of monoamine oxidase type B

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi

24 May 2018

1 reference

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Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors

24 May 2018

1 reference

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Three-part inventions: intracellular signaling and induced proximity

24 May 2018

1 reference

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Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas

24 May 2018

1 reference

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Beta-adrenoceptor blockers and the blood-brian barrier

24 May 2018

1 reference

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Rapid and reversible translocation of the catalytic subunit of cAMP-dependent protein kinase type II from the Golgi complex to the nucleus

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Beta 1- and beta 2-adrenoceptors in the human heart: properties, function, and alterations in chronic heart failure

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Distinct regulation of beta 1- and beta 2-adrenergic receptors in Chinese hamster fibroblasts

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Presence of adenylate cyclase activity in Golgi and other fractions from rat liver. II. Cytochemical localization within Golgi and ER membranes

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Presence of adenylate cyclase activity in Golgi and other fractions from rat liver. I. Biochemical determination

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

CGP-12177. A hydrophilic beta-adrenergic receptor radioligand reveals high affinity binding of agonists to intact cells.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation.

3 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y2 receptor ligands.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Trimeric G protein alpha subunits of the Gs and Gi families localized at the Golgi membrane.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5733145

Location-dependent signaling of the group 1 metabotropic glutamate receptor mGlu5.

15 August 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2389

Cyclic-AMP-dependent protein kinase type II is associated with the Golgi complex and with centrosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2389

Positive and Negative Inotropic Effects of dl -Sotalol and d -Sotalol in Failing and Nonfailing Human Myocardium Under Physiological Experimental Conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2389

7 January 2021

inferred from DOI database lookup

Inotropic and haemodynamic effects of d- and d,l-sotalol: comparison with other antiarrhythmics

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2389

7 January 2021

inferred from DOI database lookup

The ESCRT machinery mediates polarization of fibroblasts through regulation of myosin light chain

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2389

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCHEMBIO.2389

1 reference

25 December 2017

PMC publication ID

5733145

1 reference

25 December 2017

PubMed publication ID

28553949

1 reference

25 December 2017