(Q46779933)

25 December 2017

title

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ (English)

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25 December 2017

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Tony Wyss-Coray

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25 December 2017

author name string

John D Loike

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Thomas C Brionne

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Emily Lu

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Roman Anankov

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Fengrong Yan

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Samuel C Silverstein

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Jens Husemann

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25 December 2017

language of work or name

English

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publication date

3 March 2003

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25 December 2017

published in

Nature Medicine

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25 December 2017

volume

9

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issue

4

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25 December 2017

page(s)

453-457

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25 December 2017

https://scigraph.springernature.com/pub.10.1038/nm838

exact match

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cites work

Mouse astrocytes respond to the chemokines MCP-1 and KC, but reverse transcriptase-polymerase chain reaction does not detect mRNA for the KC or new MCP-1 receptor.

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Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid

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7 January 2021

Microglia cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plague degradation

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7 January 2021

beta-Amyloid immunoreactivity in astrocytes in Alzheimer's disease brain biopsies: an electron microscope study.

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Amyloid beta-protein (Abeta)-containing astrocytes are located preferentially near N-terminal-truncated Abeta deposits in the human entorhinal cortex.

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Diffuse plaques associated with astroglial amyloid beta protein, possibly showing a disappearing stage of senile plaques.

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7 January 2021

Amyloid beta protein (A beta) removal by neuroglial cells in culture

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7 January 2021

Inflammation in neurodegenerative disease--a double-edged sword

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7 January 2021

Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease.

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7 January 2021

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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7 January 2021

Microglia and astrocytes in the adult rat brain: comparative immunocytochemical analysis demonstrates the efficacy of lipocortin 1 immunoreactivity

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7 January 2021

Establishment of human adult astrocyte cultures derived from postmortem multiple sclerosis and control brain and spinal cord regions: immunophenotypical and functional characterization.

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7 January 2021

CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils

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7 January 2021

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor.

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7 January 2021

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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7 January 2021

Identifiers

DOI

10.1038/NM838

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25 December 2017

PubMed ID

12612547

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25 December 2017