(Q46781276)

25 December 2017

title

Synthesis and biological activity of a novel inhibitor of dihydroceramide desaturase (English)

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25 December 2017

author

Carmen Bedia

3

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25 December 2017

Amadeu Llebaria

6

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25 December 2017

author name string

Jose M Munoz-Olaya

1

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25 December 2017

Xavier Matabosch

2

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25 December 2017

Meritxell Egido-Gabás

4

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25 December 2017

Josefina Casas

5

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25 December 2017

Antonio Delgado

7

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25 December 2017

Gemma Fabriàs

8

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25 December 2017

publication date

1 June 2008

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25 December 2017

published in

ChemMedChem

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25 December 2017

volume

3

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25 December 2017

page(s)

946-953

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25 December 2017

issue

6

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25 December 2017

Ceramide mediates tumor-induced dendritic cell apoptosis

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

Degenerative spermatocyte, a novel gene encoding a transmembrane protein required for the initiation of meiosis in Drosophila spermatogenesis

21 January 2018

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https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Mdes, a mouse homolog of the Drosophila degenerative spermatocyte gene is expressed during mouse spermatogenesis.

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https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Identification and characterization of a sphingolipid delta 4-desaturase family

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https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Identification of an essential sequence for dihydroceramide C-4 hydroxylase activity of mouse DES2

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

C2-ceramide induces apoptosis in a human squamous cell carcinoma cell line

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Dihydroceramide hinders ceramide channel formation: Implications on apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Synthesis of a Cyclopropene Analogue of Ceramide, a Potent Inhibitor of Dihydroceramide Desaturase This work was supported by the Dirección General de Enseñanza Superior e Investigación Científica (grant PB97-1171) and the Departament d'Universitats

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Synthesis of cyclopropene analogues of ceramide and their effect on dihydroceramide desaturase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Analogs of the dihydroceramide desaturase inhibitor GT11 modified at the amide function: synthesis and biological activities

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Specificity of the dihydroceramide desaturase inhibitor N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in primary cultured cerebellar neurons.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Dihydroceramide biology. Structure-specific metabolism and intracellular localization

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

A new class of lipoxygenase inhibitor. Polyunsaturated fatty acids containing sulfur

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Dihydroceramide delta(4) desaturase initiates substrate oxidation at C-4.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Chain cleavage and sulfoxidation of thiastearoyl-ACP upon reaction with stearoyl-ACP desaturase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Desaturation, chain scission, and register-shift of oxygen-substituted fatty acids during reaction with stearoyl-ACP desaturase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Sphingomyelin synthase 1 suppresses ceramide production and apoptosis post-photodamage

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

C16 ceramide accumulates following androgen ablation in LNCaP prostate cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Importance of C16 ceramide accumulation during apoptosis in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Mass spectrometric identification of increased C16 ceramide levels during apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Fas, ceramide and serum withdrawal induce apoptosis via a common pathway in a type II Jurkat cell line.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Coenzyme Q protects cells against serum withdrawal-induced apoptosis by inhibition of ceramide release and caspase-3 activation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Role for ceramide in cell cycle arrest.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Apoptosis of human abdominal preadipocytes before and after differentiation into adipocytes in culture.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Role of ceramide in cellular senescence

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Altered de novo sphingolipid biosynthesis is involved in the serum deprivation-induced cell death in LLC-PK1 cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700325

7 January 2021

Identifiers

DOI

10.1002/CMDC.200700325

1 reference

25 December 2017

PubMed ID

18236489

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25 December 2017