(Q46818702)

English

Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1.

scientific article published in November 2005

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16306414%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1 (English)

1 reference

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9 January 2020

author name string

Gusheng Wu

1

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9 January 2020

Zi-Hua Lu

2

1 reference

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9 January 2020

Jianfeng Wang

3

1 reference

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9 January 2020

Yvette Wang

4

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9 January 2020

Xin Xie

5

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9 January 2020

Markus F Meyenhofer

6

1 reference

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9 January 2020

Robert W Ledeen

7

1 reference

Europe PubMed Central

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9 January 2020

language of work or name

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publication date

1 November 2005

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Europe PubMed Central

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9 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

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9 January 2020

25

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9 January 2020

47

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Europe PubMed Central

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9 January 2020

11014-11022

1 reference

Europe PubMed Central

PMC publication ID

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9 January 2020

A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental appearance of nuclear GM1 in neurons of the central and peripheral nervous systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonogenesis in neuro-2a cells correlates with GM1 upregulation in the nuclear and plasma membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonistic effect of ganglioside GM1 and GM3 on the activity and conformation of sarcoplasmic reticulum Ca(2+)-ATPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear calcium signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gangliosides and growth factor receptor regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kainate, a double agent that generates seizures: two decades of progress

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebellar neurons lacking complex gangliosides degenerate in the presence of depolarizing levels of potassium

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant NG108-15 cells (NG-CR72) deficient in GM1 synthase respond aberrantly to axonogenic stimuli and are vulnerable to calcium-induced apoptosis: they are rescued with LIGA-20.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heightened seizure severity in somatostatin knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Na,K-ATPase in the nuclear envelope regulates Na+: K+ gradients in hepatocyte nuclei.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potentiation of a sodium-calcium exchanger in the nuclear envelope by nuclear GM1 ganglioside.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ganglioside function in calcium homeostasis and signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple method for the isolation and purification of total lipides from animal tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE GANGLIOSIDES.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spatial organization of Ca2+ signalling and Ins(1,4,5)P3 action

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C6 cells express a sodium-calcium exchanger/GM1 complex in the nuclear envelope but have no exchanger in the plasma membrane: comparison to astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Infantile-onset symptomatic epilepsy syndrome caused by a homozygous loss-of-function mutation of GM3 synthase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of sodium-calcium exchanger/GM1 complex in the nuclear envelope of non-neural cells: nature of exchanger-GM1 interaction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ganglioside modulation of neural cell adhesion molecule and N-cadherin-dependent neurite outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a GM1-binding protein on the surface of murine neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: protection by synthetic derivatives of endogenous sphingolipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gangliosides improve a memory deficit in pentylenetetrazol-kindled rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gangliosides normalize distorted single-cell intracellular free Ca2+ dynamics after toxic doses of glutamate in cerebellar granule cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory amino acid neurotoxicity and neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of protein kinase C activity by gangliosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ganglioside function in the development and repair of the nervous system. From basic science to clinical application

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of amygdala kindling by intracerebroventricularly administered gangliosides in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantification of gangliotetraose gangliosides with cholera toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ganglioside changes associated with temporal lobe epilepsy in the human hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of exogenous GM1 ganglioside on kindled-amygdaloid seizures

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thyroid hormone influence on the susceptibility of mice to audiogenic seizures

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological activities of antibodies injected into the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simplified procedure for the preparation of tritiated GM1 ganglioside and other glycosphingolipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gangliosides: structure, isolation, and analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ganglioside receptors and induction of epileptiform activity: cholera toxin and choleragenoid (B subunits).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous ganglioside GM1 modulates L-type calcium channel activity in N18 neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ganglioside GM1 binds to the Trk protein and regulates receptor function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Response of the damaged dopamine system to GM1 and semisynthetic gangliosides: effects of dose and extent of lesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GM1 ganglioside in the nuclear membrane modulates nuclear calcium homeostasis during neurite outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induced and spontaneous neuritogenesis are associated with enhanced expression of ganglioside GM1 in the nuclear membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation by GM1 ganglioside of beta 1-adrenergic receptor-induced cyclic AMP formation in Sf9 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium and excitotoxic neuronal injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of apoptotic neuronal death by GM1 ganglioside. Involvement of Trk neurotrophin receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain content of glycosphingolipids after oral administration of monosialogangliosides GM1 and LIGA20 to rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nucleus is insulated from large cytosolic calcium ion changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LIGA20, a lyso derivative of ganglioside GM1, given orally after cortical thrombosis reduces infarct size and associated cognition deficit

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by gangliosides against glutamate excitotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LIGA 20 increases striatal dopamine levels in aged MPTP-treated mice refractory to GM1 ganglioside treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular parameters of semisynthetic derivatives of gangliosides and sphingosine in monolayers at the air-water interface

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gangliosides and glycosphingolipids as modulators of cell growth, adhesion, and transmembrane signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and purification of a calcium-binding protein in hepatic nuclear membranes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inositol 1,4,5-trisphosphate receptor is located to the inner nuclear membrane vindicating regulation of nuclear calcium signaling by inositol 1,4,5-trisphosphate. Discrete distribution of inositol phosphate receptors to inner and outer nuclear memb

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GM1 ganglioside modulates prostaglandin E1 stimulated adenylyl cyclase in neuro-2A cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of the delta-opioid receptor with GM1 ganglioside: conversion from inhibitory to excitatory mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current evidence suggests independent regulation of nuclear calcium

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The calcium store in the nuclear envelope

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of GM1 and other gangliosides in neuronal differentiation. Overview and new finding

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of endogenous GM1 ganglioside on TrkB activity, in cultured neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of nuclear GM1 accompanies axon-like, but not dendrite-like, outgrowth in NG108-15 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306414

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3635-05.2005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16306414%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16306414%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16306414%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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