(Q46823363)

25 December 2017

title

Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase (English)

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25 December 2017

abdominal aortic aneurysm

main subject

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3

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Romeo Ricci

9

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25 December 2017

author name string

Koichi Yoshimura

1

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25 December 2017

Hiroki Aoki

2

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Kozo Fujii

4

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Norio Akiyama

5

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Akira Furutani

6

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Yoshinobu Hoshii

7

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Nobuyuki Tanaka

8

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Tokuhiro Ishihara

10

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Kensuke Esato

11

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Kimikazu Hamano

12

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Masunori Matsuzaki

13

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language of work or name

English

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publication date

27 November 2005

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25 December 2017

published in

Nature Medicine

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25 December 2017

volume

11

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issue

12

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page(s)

1330-1338

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https://scigraph.springernature.com/pub.10.1038/nm1335

exact match

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cites work

Gene therapy to treat aortic aneurysms: right goal, wrong strategy

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7 January 2021

Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms

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7 January 2021

Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms

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7 January 2021

Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model

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7 January 2021

Elastogenesis in human arterial disease: a role for macrophages in disordered elastin synthesis

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7 January 2021

Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms

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7 January 2021

Increased amount of type III pN-collagen in AAA when compared with AOD

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7 January 2021

The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms

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7 January 2021

Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase

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7 January 2021

Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice

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7 January 2021

Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study

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7 January 2021

Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study.

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7 January 2021

Vascular smooth muscle cell endovascular therapy stabilizes already developed aneurysms in a model of aortic injury elicited by inflammation and proteolysis

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7 January 2021

Increased synthesis of matrix metalloproteinases by aortic smooth muscle cells is implicated in the etiopathogenesis of abdominal aortic aneurysms

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7 January 2021

Targeting JNK for therapeutic benefit: from junk to gold?

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7 January 2021

Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly.

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7 January 2021

Transcriptional activation of scavenger receptor expression in human smooth muscle cells requires AP-1/c-Jun and C/EBPbeta: both AP-1 binding and JNK activation are induced by phorbol esters and oxidative stress

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7 January 2021

The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL.

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7 January 2021

Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice

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7 January 2021

Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis

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7 January 2021

Bistability in the JNK cascade

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7 January 2021

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

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7 January 2021

Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice

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7 January 2021

An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression

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7 January 2021

Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades

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7 January 2021

Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cells

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7 January 2021

JNK regulates autocrine expression of TGF-beta1.

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7 January 2021

Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts

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7 January 2021

Collagen synthesis in cultured aortic smooth muscle cells. Modulation by collagen lattice culture, transforming growth factor-beta 1, and epidermal growth factor

1 reference

7 January 2021

Overexpression of transforming growth factor-beta1 stabilizes already-formed aortic aneurysms: a first approach to induction of functional healing by endovascular gene therapy

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7 January 2021

Suppression of experimental abdominal aortic aneurysms in mice by treatment with pyrrolidine dithiocarbamate, an antioxidant inhibitor of nuclear factor-kappaB.

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7 January 2021

Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors

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7 January 2021

Doxycycline inhibits TGF-beta1-induced MMP-9 via Smad and MAPK pathways in human corneal epithelial cells

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7 January 2021

Linking JNK signaling to NF-kappaB: a key to survival

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7 January 2021

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

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7 January 2021

Proteasome‐dependent decrease in Akt by growth factors in vascular smooth muscle cells

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7 January 2021

Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes

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7 January 2021

Matrix metalloproteinases of vascular wall cells are increased in balloon-injured rat carotid artery.

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7 January 2021

A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples

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7 January 2021

Identifiers

DOI

10.1038/NM1335

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25 December 2017

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25 December 2017