(Q46827814)

25 December 2017

title

The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation (English)

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25 December 2017

6

Xu Shen

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25 December 2017

author name string

Fei Ye

1

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25 December 2017

Zhen-Shan Zhang

2

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25 December 2017

Hai-Bin Luo

3

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25 December 2017

Jian-Hua Shen

4

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25 December 2017

Kai-Xian Chen

5

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25 December 2017

Hua-Liang Jiang

7

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25 December 2017

publication date

1 January 2006

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25 December 2017

published in

ChemBioChem

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25 December 2017

volume

7

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25 December 2017

issue

1

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25 December 2017

page(s)

74-82

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25 December 2017

describes a project that uses

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The nuclear receptor superfamily: the second decade

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https://api.crossref.org/works/10.1002%2FCBIC.200500186

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

PPARgamma, the ultimate thrifty gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Peroxisome proliferator-activated receptor-gamma2 polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes: The Berlin Diabetes Mellitus (BeDiaM) Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

A novel potent antagonist of peroxisome proliferator-activated receptor gamma blocks adipocyte differentiation but does not revert the phenotype of terminally differentiated adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

The conserved residue Phe273(282) of PPARalpha(gamma), beyond the ligand-binding site, functions in binding affinity through solvation effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

The PPARs: from orphan receptors to drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

A regulatory role for RIP140 in nuclear receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Ligand-binding regulation of LXR/RXR and LXR/PPAR heterodimerizations: SPR technology-based kinetic analysis correlated with molecular dynamics simulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Nuclear receptors as targets for drug development: molecular mechanisms for regulation of obesity and insulin resistance by peroxisome proliferator-activated receptor gamma, CREB-binding protein, and adiponectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Effects of mitogen-activated protein kinase pathway and co-activator CREP-binding protein on peroxisome proliferator-activated receptor-gamma-mediated transcription suppression of angiotensin II type 1 receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Use of homogeneous time-resolved fluorescence energy transfer in the measurement of nuclear receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

alpha-Galactosidase from Saccharomyces carlsbergensis. Cellular localization, and purification of the external enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Binding of prostaglandins to human PPARgamma: tool assessment and new natural ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Strategic approaches to drug design. I. An integrated software framework for molecular modelling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Iterative partial equalization of orbital electronegativity—a rapid access to atomic charges

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.200500186

21 January 2018

Identifiers

DOI

10.1002/CBIC.200500186

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25 December 2017

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25 December 2017