(Q46857215)

English

Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist

scientific article published on 16 December 2005

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

Ulrike Holzgrabe

4

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

author name string

Maren Grossmüller

1

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

Johannes Antony

2

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

Christian Tränkle

3

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

Klaus Mohr

5

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

publication date

16 December 2005

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

Naunyn-Schmiedeberg's Archives of Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

372

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

4

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

267-276

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

Allosteric site on muscarinic acetylcholine receptors: a single amino acid in transmembrane region 7 is critical to the subtype selectivities of caracurine V derivatives and alkane-bisammonium ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

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Allosteric modulation of G protein-coupled receptors: perspectives and recent developments

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposite effects of alcuronium on agonist and on antagonist binding to muscarinic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed mutagenesis reveals two epitopes involved in the subtype selectivity of the allosteric interactions of gallamine at muscarinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence of paired M2 muscarinic receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperative interactions at M2 muscarinic acetylcholine receptors: structure/activity relationships in stepwise shortened bispyridinium- and bis(ammonio)alkane-type allosteric modulators

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor: more similarities than differences between the structurally divergent agents gallamine and bis(ammonio)alkane-type hexamethylene-bis-[dimethyl-(3

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The air-perfused bronchial tree

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

M2 receptor binding of the selective antagonist AF-DX 384: possible involvement of the common allosteric site.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric modulation of muscarinic receptor signaling: alcuronium-induced conversion of pilocarpine from an agonist into an antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of Mg2+ with the allosteric site of muscarinic M2 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscarinic allosteric enhancers of ligand binding: pivotal pharmacophoric elements in hexamethonio-type agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric regulation of the binding of [3H]acetylcholine to m2 muscarinic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-o

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymethylene tetraamines as muscarinic receptor probes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Search for the Pharmacophore of Bispyridinium-Type Allosteric Modulators of Muscarinic Receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Seven-transmembrane receptors: crystals clarify

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosteric binding sites on muscarinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of signal transduction at M2 muscarinic receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modes of allosteric interactions with free and [3H]N-methylscopolamine-occupied muscarinic M2 receptors as deduced from buffer-dependent potency shifts

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure/activity relationships of M2 muscarinic allosteric modulators

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergent modes of action among cationic allosteric modulators of muscarinic M2 receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two allosteric modulators interact at a common site on cardiac muscarinic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of a new type of allosteric modulator of muscarinic receptors: hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allosterism at muscarinic receptors: ligands and mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model of the human M2 muscarinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and activation of muscarinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of acidic amino acids in the allosteric modulation by gallamine of antagonist binding at the m2 muscarinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed mutagenesis of the putative human muscarinic M2 receptor binding site

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G protein-coupled receptor allosterism and complexing

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes of cooperativity between N-methylscopolamine and allosteric modulators alcuronium and gallamine induced by mutations of external loops of muscarinic M(3) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Search for lead structures to develop new allosteric modulators of muscarinic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positive cooperativity in the binding of alcuronium and N-methylscopolamine to muscarinic acetylcholine receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of alcuronium, TMB-8, and other allosteric ligands with muscarinic acetylcholine receptors: studies with chimeric receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of the binding properties of muscarinic receptors by gallamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16362429

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00210-005-0023-4

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16362429

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