(Q46865480)

English

Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle

scientific article published in December 2007

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scholarly article

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle (English)

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

lipopolysaccharide

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toll-like receptor

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1 reference

based on heuristic

inferred from title

insulin resistance

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based on heuristic

inferred from title

author name string

M S Radin

1

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

S Sinha

2

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

B A Bhatt

3

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

N Dedousis

4

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

R M O'Doherty

5

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

publication date

1 December 2007

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

51

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

2

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

336-346

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Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

https://scigraph.springernature.com/pub.10.1007/s00125-007-0861-3

0 references

C-reactive protein, insulin resistance, central obesity, and coronary heart disease risk in Indian Asians from the United Kingdom compared with European whites.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-007-0861-3

21 January 2018

Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory status and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A genetic basis for the "Adonis" phenotype of low adiposity and strong bones.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IKK-beta links inflammation to obesity-induced insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of insulin-stimulated skeletal muscle glucose uptake in conscious rat using isotopic glucose analogs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of fat-induced insulin resistance by salicylate

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A central role for JNK in obesity and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TLR4 links innate immunity and fatty acid-induced insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Innate immune sensing and its roots: the story of endotoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TIRAP: an adapter molecule in the Toll signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obesity is associated with macrophage accumulation in adipose tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inferences, questions and possibilities in Toll-like receptor signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diet-induced obesity and acute hyperlipidemia reduce IkappaBalpha levels in rat skeletal muscle in a fiber-type dependent manner.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/18060381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-007-0861-3

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

1 reference

Europe PubMed Central

25 December 2017

http://europepmc.org/abstract/MED/18060381

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