(Q46903679)

26 December 2017

http://europepmc.org/abstract/MED/16426422

title

ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis (English)

1 reference

26 December 2017

http://europepmc.org/abstract/MED/16426422

1 reference

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496121&resulttype=core&format=json

14 May 2020

Zbyszek Darzynkiewicz

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496121&resulttype=core&format=json

14 May 2020

author name string

T Tanaka

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496121&resulttype=core&format=json

14 May 2020

A Kurose

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496121&resulttype=core&format=json

14 May 2020

X Huang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496121&resulttype=core&format=json

14 May 2020

publication date

1 February 2006

1 reference

26 December 2017

http://europepmc.org/abstract/MED/16426422

published in

Cell Proliferation

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496121&resulttype=core&format=json

14 May 2020

volume

39

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496121&resulttype=core&format=json

14 May 2020

issue

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496121&resulttype=core&format=json

14 May 2020

page(s)

49-60

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496121&resulttype=core&format=json

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

14 May 2020

cites work

1 reference

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Initiating cellular stress responses

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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Chk1 and Chk2 kinases in checkpoint control and cancer

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Checking on DNA damage in S phase

21 January 2018

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ATM activation in normal human tissues and testicular cancer

21 January 2018

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

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H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity

21 January 2018

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The cellular response to general and programmed DNA double strand breaks

21 January 2018

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

21 January 2018

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Features of apoptotic cells measured by flow cytometry

21 January 2018

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The S-phase cytotoxicity of camptothecin.

21 January 2018

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Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

21 January 2018

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Ataxia telangiectasia mutated expression and activation in the testis

21 January 2018

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Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin

21 January 2018

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Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis

21 January 2018

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

21 January 2018

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Cell-cycle checkpoints and cancer

21 January 2018

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The many substrates and functions of ATM

21 January 2018

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Cdc25 phosphatases and cancer

21 January 2018

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Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis

21 January 2018

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

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DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner

21 January 2018

1 reference

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

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Evolutionary conservation of histone macroH2A subtypes and domains

21 January 2018

1 reference

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

1 reference

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

21 January 2018

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21 January 2018

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p53 localization at centrosomes during mitosis and postmitotic checkpoint are ATM-dependent and require serine 15 phosphorylation.

21 January 2018

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Processing of topoisomerase I cleavable complexes into DNA damage by transcription.

21 January 2018

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Histone H2AX in DNA damage and repair.

21 January 2018

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12 December 2020

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons

1 reference

12 December 2020

Phylogenetic analysis of the core histones H2A, H2B, H3, and H4

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12 December 2020

Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis).

1 reference

12 December 2020

Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody

1 reference

12 December 2020

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

1 reference

12 December 2020

The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents

1 reference

12 December 2020

DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis

1 reference

12 December 2020

Histone H2AX phosphorylation after cell irradiation with UV-B: relationship to cell cycle phase and induction of apoptosis.

1 reference

12 December 2020

Cell Cycle-Dependent Expression of Phosphorylated Histone H2AX: Reduced Expression in Unirradiated but not X-Irradiated G1-Phase Cells

1 reference

12 December 2020

Histone 2A, a heteromorphous family of eight protein species

1 reference

12 December 2020

10.1111/J.1365-2184.2006.00364.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496121&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6496121&resulttype=core&format=json

14 May 2020

1 reference