(Q46934015)

2 July 2019

title

CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction (English)

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2 July 2019

author name string

Andrea Gaedigk

1

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2 July 2019

Uwe Fuhr

2

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2 July 2019

Charlene Johnson

3

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2 July 2019

L Anick Bérard

4

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2 July 2019

Dianne Bradford

5

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2 July 2019

J Steven Leeder

6

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2 July 2019

publication date

1 January 2010

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2 July 2019

published in

Pharmacogenomics

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2 July 2019

volume

11

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2 July 2019

issue

1

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2 July 2019

page(s)

43-53

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2 July 2019

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

cites work

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.133

Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.09.133

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.133

Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.133

CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.133

An unequal cross-over event within the CYP2D gene cluster generates a chimeric CYP2D7/CYP2D6 gene which is associated with the poor metabolizer phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.133

The CYP2D6 gene locus in South African Coloureds: unique allele distributions, novel alleles and gene arrangements.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.133

The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.133

Mechanisms of change in gene copy number

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.133

Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.133

Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism: in vitro functional analysis of recombinant proteins expressed in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.133

Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.09.133

Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.09.133

Pharmacogenetic insights into codeine analgesia: implications to pediatric codeine use.

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.09.133

Molecular drive in multigene families: How biological novelties arise, spread and are assimilated

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.09.133

Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data

21 January 2018

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12 December 2020

CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure

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12 December 2020

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

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12 December 2020

Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene

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12 December 2020

Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype

1 reference

12 December 2020

CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles.

1 reference

12 December 2020

Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes

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12 December 2020

Identifiers

DOI

10.2217/PGS.09.133

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2 July 2019

PMC publication ID

6556886

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2 July 2019

PubMed publication ID

20017671

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2 July 2019