(Q46960355)

English

The lipoprotein receptor-related protein-1 (LRP) adapter protein GULP mediates trafficking of the LRP ligand prosaposin, leading to sphingolipid and free cholesterol accumulation in late endosomes and impaired efflux

scientific article published on 22 February 2006

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scholarly article

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

The lipoprotein receptor-related protein-1 (LRP) adapter protein GULP mediates trafficking of the LRP ligand prosaposin, leading to sphingolipid and free cholesterol accumulation in late endosomes and impaired efflux (English)

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

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Kodi Ravichandran

7

object named as

Kodi S Ravichandran

1 reference

Europe PubMed Central

26 December 2017

Kumiko Nakada-Tsukui

3

object named as

Kumiko Nakada-Tsukui

1 reference

Europe PubMed Central

26 December 2017

author name string

Robert S Kiss

1

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

Zhong Ma

2

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

Enrico Brugnera

4

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

Gerard Vassiliou

5

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

Heidi M McBride

6

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

Yves L Marcel

8

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

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publication date

22 February 2006

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Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

Journal of Biological Chemistry

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Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

281

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Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

12081-12092

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26 December 2017

http://europepmc.org/abstract/MED/16497666

17

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

Cues for apoptotic cell engulfment: eat-me, don't eat-me and come-get-me signals

1 reference

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21 January 2018

Apoptosis: giving phosphatidylserine recognition an assist--with a twist

1 reference

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21 January 2018

Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

LRP: a multifunctional scavenger and signaling receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine

1 reference

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21 January 2018

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

1 reference

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21 January 2018

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

1 reference

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21 January 2018

Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred

1 reference

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21 January 2018

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

1 reference

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21 January 2018

ATP-binding cassette transporter AI and its role in HDL formation

1 reference

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21 January 2018

Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules

1 reference

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21 January 2018

Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Identification and characterization of a dimerization domain in CED-6, an adapter protein involved in engulfment of apoptotic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

The human homologue of Caenorhabditis elegans CED-6 specifically promotes phagocytosis of apoptotic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Endocytosis and sorting of glycosphingolipids in sphingolipid storage disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Endocytic trafficking of glycosphingolipids in sphingolipid storage diseases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

The pathophysiology and mechanisms of NP-C disease.

1 reference

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21 January 2018

Sphingolipid storage induces accumulation of intracellular cholesterol by stimulating SREBP-1 cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Impaired ABCA1-dependent lipid efflux and hypoalphalipoproteinemia in human Niemann-Pick type C disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor-related protein (LRP).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Metal chelate affinity chromatography, a new approach to protein fractionation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

The low density lipoprotein receptor-related protein contributes to selective uptake of high density lipoprotein cholesteryl esters by SW872 liposarcoma cells and primary human adipocytes

1 reference

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21 January 2018

Functional expression of the chicken low density lipoprotein receptor-related protein in a mutant chinese hamster ovary cell line restores toxicity of Pseudomonas exotoxin A and degradation of alpha2-macroglobulin.

1 reference

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21 January 2018

A radiation-induced murine ovarian granulosa cell tumor line: introduction of v-ras gene potentiates a high metastatic ability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Prosaposin deficiency -- a rarely diagnosed, rapidly progressing, neonatal neurovisceral lipid storage disease. Report of a further patient.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Lipid efflux in human and mouse macrophagic cells: evidence for differential regulation of phospholipid and cholesterol efflux

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Lipid and cholesterol trafficking in NPC.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Rab proteins as membrane organizers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Type C Niemann-Pick disease: documentation of abnormal LDL processing in lymphocytes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

The N370S (Asn370-->Ser) mutation affects the capacity of glucosylceramidase to interact with anionic phospholipid-containing membranes and saposin C

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Glucosylceramidase mass and subcellular localization are modulated by cholesterol in Niemann-Pick disease type C.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

NPC2 is expressed in human and murine liver and secreted into bile: potential implications for body cholesterol homeostasis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis

1 reference

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21 January 2018

NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols

1 reference

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21 January 2018

The insulin-stimulated cell surface presentation of low density lipoprotein receptor-related protein in 3T3-L1 adipocytes is sensitive to phosphatidylinositide 3-kinase inhibition.

1 reference

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21 January 2018

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

1 reference

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21 January 2018

Remodeling of endosomes during lysosome biogenesis involves 'kiss and run' fusion events regulated by rab5.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Rab conversion as a mechanism of progression from early to late endosomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Purified recombinant human prosaposin forms oligomers that bind procathepsin D and affect its autoactivation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M600621200

21 January 2018

Gaucher disease mouse models: point mutations at the acid beta-glucosidase locus combined with low-level prosaposin expression lead to disease variants.

1 reference

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21 January 2018

Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides

1 reference

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21 January 2018

Binding and transport of gangliosides by prosaposin

1 reference

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21 January 2018

Biosynthesis, processing, and targeting of sphingolipid activator protein (SAP )precursor in cultured human fibroblasts. Mannose 6-phosphate receptor-independent endocytosis of SAP precursor

1 reference

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21 January 2018

The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin

1 reference

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21 January 2018

Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids.

1 reference

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21 January 2018

A novel mutation in the coding region of the prosaposin gene leads to a complete deficiency of prosaposin and saposins, and is associated with a complex sphingolipidosis dominated by lactosylceramide accumulation

1 reference

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21 January 2018

Lactosylceramide in lysosomal storage disorders: a comparative immunohistochemical and biochemical study

1 reference

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21 January 2018

Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux

1 reference

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21 January 2018

Niemann-Pick type C mutations cause lipid traffic jam.

1 reference

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21 January 2018

Proteolytic processing patterns of prosaposin in insect and mammalian cells

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M600621200

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

1 reference

Europe PubMed Central

26 December 2017

http://europepmc.org/abstract/MED/16497666

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