(Q46990198)

27 December 2017

title

Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells (English)

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27 December 2017

main subject

hispidulin

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ChEBI release 2020-05-28

Hui Gao

1

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27 December 2017

Hui Wang

series ordinal

2

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27 December 2017

Jianjun Peng

series ordinal

3

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27 December 2017

publication date

1 May 2014

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27 December 2017

Cell Biochemistry and Biophysics

published in

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27 December 2017

volume

69

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27 December 2017

issue

1

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27 December 2017

page(s)

27-34

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27 December 2017

Treatment of hepatocellular carcinoma (HCC) by intra-arterial infusion of radio-emitter compounds: trans-arterial radio-embolisation of HCC.

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Systemic therapy for hepatocellular carcinoma: cytotoxic chemotherapy, targeted therapy and immunotherapy.

21 January 2018

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Inhibition of epidermal growth factor receptor signaling by Saussurea involucrata, a rare traditional Chinese medicinal herb, in human hormone-resistant prostate cancer PC-3 cells

21 January 2018

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Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita

21 January 2018

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The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects

21 January 2018

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Mono- and sesquiterpenes and antifungal constituents from Artemisia species

21 January 2018

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Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship

21 January 2018

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Flavonoids as superoxide scavengers and antioxidants

21 January 2018

1 reference

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Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9762-X

Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9762-X

Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathway.

21 January 2018

1 reference

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Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway

21 January 2018

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Hispidulin: antioxidant properties and effect on mitochondrial energy metabolism

21 January 2018

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The molecular effects of aloe-emodin (AE)/liposome-AE on human nonmelanoma skin cancer cells and skin permeation

21 January 2018

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Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells

21 January 2018

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21 January 2018

Liver cancer on the rise

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Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway

21 January 2018

1 reference

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Importance of the core structure of flavones in promoting inhibition of the mitochondrial respiratory chain

21 January 2018

1 reference

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Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner

21 January 2018

1 reference

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Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

1 reference

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

21 January 2018

1 reference

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Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibi

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12013-013-9762-X

10.1007/S12013-013-9762-X

21 January 2018

Identifiers

DOI

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27 December 2017

1 reference

27 December 2017