(Q47070046)

English

Learning and memory deficits consequent to reduction of the fragile X mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila.

scientific article published in September 2012

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scholarly article

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13 February 2020

Learning and memory deficits consequent to reduction of the fragile X mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila (English)

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13 February 2020

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Fmr1 Dmel_CG6203

1 reference

GOA release 2020-03-11

Ourania Semelidou

2

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13 February 2020

Andriana G Kotini

3

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13 February 2020

author name string

Alexandros K Kanellopoulos

1

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13 February 2020

Maria Anezaki

4

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13 February 2020

Efthimios M C Skoulakis

5

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13 February 2020

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1 September 2012

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13 February 2020

Journal of Neuroscience

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13 February 2020

32

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13 February 2020

38

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13 February 2020

13111-13124

1 reference

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13 February 2020

Effects of rolipram on the elevated plus-maze test in rats: a preliminary study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel Drosophila alkaline phosphatase specific to the ellipsoid body of the adult brain and the lower Malpighian (renal) tubule

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Spatial learning, contextual fear conditioning and conditioned emotional response in Fmr1 knockout mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Localization of long-term memory within the Drosophila mushroom body.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

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Behavioral and neuroanatomical characterization of the Fmr1 knockout mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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A decade of molecular studies of fragile X syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Casein kinase II phosphorylates the fragile X mental retardation protein and modulates its biological properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Sunrise at the synapse: the FMRP mRNP shaping the synaptic interface

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Mushroom body memoir: from maps to models

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological characterization and immunoaffinity purification of metabotropic glutamate receptor from Drosophila overexpressed in Sf9 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic AMP metabolism in fragile X syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spatiotemporal rescue of memory dysfunction in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fragile-X premutation: a maturing perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mGluR theory of fragile X mental retardation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Repetitive exposures to nicotine induce a hyper-responsiveness via the cAMP/PKA/CREB signal pathway in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropsychiatric symptoms of fragile X syndrome: pathophysiology and pharmacotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Olfactory memory formation in Drosophila: from molecular to systems neuroscience.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Come FLY with us: toward understanding fragile X syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Expression profiling suggests underexpression of the GABA(A) receptor subunit delta in the fragile X knockout mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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The gene encoding the fragile X RNA-binding protein is controlled by nuclear respiratory factor 2 and the CREB family of transcription factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Dunces and da Vincis: the genetics of learning and memory in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Fragile-X syndrome and fragile X-associated tremor/ataxia syndrome: two faces of FMR1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Distinct neuronal circuits mediate experience-dependent, non-associative osmotactic responses in Drosophila.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Fragile X tremor/ataxia syndrome: blame the messenger!

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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The cyclic AMP cascade is altered in the fragile X nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanistic relationships between Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Widespread brain distribution of the Drosophila metabotropic glutamate receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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The cyclic AMP phosphodiesterase encoded by the Drosophila dunce gene is concentrated in the mushroom body neuropil

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigation of phenotypes associated with mood and anxiety among male and female fragile X premutation carriers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mouse model of fragile X syndrome exhibits heightened arousal and/or emotion following errors or reversal of contingencies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cyclic AMP phenotype of fragile X and autism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FMRP acts as a key messenger for dopamine modulation in the forebrain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

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Neuralized is expressed in the alpha/beta lobes of adult Drosophila mushroom bodies and facilitates olfactory long-term memory formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptor-mediated use-dependent down-regulation of synaptic excitability involves the fragile X mental retardation protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factors in long-term memory and synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mushroom body of adult Drosophila characterized by GAL4 drivers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fragile X mental retardation protein in circadian rhythmicity and memory consolidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dual role for the adaptor protein DRK in Drosophila olfactory learning and memory.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fragile X syndrome: from molecular genetics to therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent cognitive impairment in a Drosophila fragile X model and its pharmacological rescue

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Short- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of novel FMR1 variants by massively parallel sequencing in developmentally delayed males.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological reversal of synaptic plasticity deficits in the mouse model of fragile X syndrome by group II mGluR antagonist or lithium treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat homologs of the Drosophila dunce gene code for cyclic AMP phosphodiesterases sensitive to rolipram and RO 20-1724.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The FRAXopathies: Definition, overview, and update

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Psychopathology in fragile X syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classical conditioning and retention in normal and mutantDrosophila melanogaster

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential expression in mushroom bodies of the catalytic subunit of protein kinase A and its role in learning and memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic investigation of cAMP-dependent protein kinase function in Drosophila development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cyclic AMP system and Drosophila learning.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and functional expression of a Drosophila metabotropic glutamate receptor expressed in the embryonic CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FMR1 enhancer is regulated by cAMP through a cAMP-responsive element.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of fragile X gene (FMR-1) transcripts increases cAMP production in neural cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22993428

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1347-12.2012

1 reference

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13 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22993428%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22993428%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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