(Q47130925)

8 January 2018

title

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice (English)

1 reference

8 January 2018

1 reference

Kathryn F Mills

1

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8 January 2018

Shohei Yoshida

2

1 reference

8 January 2018

Liana R Stein

3

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8 January 2018

Alessia Grozio

4

1 reference

8 January 2018

Shunsuke Kubota

5

1 reference

8 January 2018

Yo Sasaki

6

1 reference

8 January 2018

Philip Redpath

7

1 reference

8 January 2018

Marie E Migaud

8

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8 January 2018

Rajendra S Apte

9

1 reference

8 January 2018

Koji Uchida

10

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8 January 2018

Jun Yoshino

11

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8 January 2018

Shin-Ichiro Imai

12

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8 January 2018

publication date

27 October 2016

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8 January 2018

published in

Cell Metabolism

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8 January 2018

volume

24

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8 January 2018

issue

6

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8 January 2018

page(s)

795-806

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8 January 2018

Metformin as a Tool to Target Aging

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Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death

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NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

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Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice.

23 May 2018

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Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

23 May 2018

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NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

23 May 2018

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SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice

23 May 2018

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Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine model

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In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences

23 May 2018

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Differences in the distribution, phenotype and gene expression of subretinal microglia/macrophages in C57BL/6N (Crb1 rd8/rd8) versus C57BL6/J (Crb1 wt/wt) mice

23 May 2018

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Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss

23 May 2018

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Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage

23 May 2018

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Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans

23 May 2018

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Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion

23 May 2018

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NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease

23 May 2018

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Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging

23 May 2018

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NAD+ and sirtuins in aging and disease

23 May 2018

1 reference

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Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

23 May 2018

1 reference

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Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

23 May 2018

1 reference

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Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH.

23 May 2018

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The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

23 May 2018

1 reference

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Mitonuclear protein imbalance as a conserved longevity mechanism

23 May 2018

1 reference

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Rapalogs and mTOR inhibitors as anti-aging therapeutics

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Age-associated changes in oxidative stress and NAD+ metabolism in human tissue.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

The NAD World: a new systemic regulatory network for metabolism and aging--Sirt1, systemic NAD biosynthesis, and their importance

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Life span extension and neuronal cell protection by Drosophila nicotinamidase

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Effect of inflammation on lacrimal gland function.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Adipose tissue, inflammation, and cardiovascular disease

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes.

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5668137

Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function

15 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28068222

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CMET.2016.09.013

1 reference

8 January 2018

PMCID

5668137

1 reference

8 January 2018

PubMed ID

28068222

1 reference

8 January 2018