(Q47269736)

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HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.

scientific article published on 20 December 2017

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7 April 2020

HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma (English)

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7 April 2020

phosphorylation

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inferred from title

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7 April 2020

author name string

Qiuran Xu

1

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7 April 2020

Jianfeng Tu

2

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7 April 2020

Changwei Dou

3

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7 April 2020

Jun Zhang

4

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7 April 2020

Liu Yang

5

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7 April 2020

Xin Liu

6

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7 April 2020

Kefeng Lei

7

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7 April 2020

Zhikui Liu

8

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7 April 2020

Yufeng Wang

9

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7 April 2020

Lijie Li

10

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7 April 2020

Hangxing Bao

11

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7 April 2020

Jiahui Wang

12

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7 April 2020

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20 December 2017

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7 April 2020

Molecular Cancer

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7 April 2020

16

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7 April 2020

1

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7 April 2020

178

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7 April 2020

Parkin Regulates the Activity of Pyruvate Kinase M2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

HSP90 inhibits apoptosis and promotes growth by regulating HIF-1α abundance in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

MicroRNA-212 suppresses tumor growth of human hepatocellular carcinoma by targeting FOXA1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Regulation of pyruvate kinase isozyme M2 is mediated by the ubiquitin-specific protease 20.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

PKM2 regulates Gli1 expression in hepatocellular carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

AMPK regulates histone H2B O-GlcNAcylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

PKM2, a Central Point of Regulation in Cancer Metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

HSP90 inhibitors for cancer therapy and overcoming drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Emerging roles of PKM2 in cell metabolism and cancer progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Targeting the dynamic HSP90 complex in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

New roles for pyruvate kinase M2: working out the Warburg effect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Pyruvate kinase M2 is a phosphotyrosine-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Pyruvate kinase type M2 and its role in tumor growth and spreading

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Pyruvate kinase type M2: a crossroad in the tumor metabolome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

Heat shock proteins in human cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

23 May 2018

CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

14 August 2018

miR-187-3p inhibits the metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting S100A4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

14 August 2018

Evaluation of Fbxw7 expression and its correlation with the expression of c-Myc, cyclin E and p53 in human hepatocellular carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5738801

14 August 2018

Heat shock proteins in human cancer

1 reference

https://api.crossref.org/works/10.1186%2FS12943-017-0748-Y

21 January 2018

Hepatocellular Carcinoma (HCC)

1 reference

https://api.crossref.org/works/10.1186%2FS12943-017-0748-Y

21 January 2018

Identifiers

10.1186/S12943-017-0748-Y

1 reference

Europe PubMed Central

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7 April 2020

Dimensions Publication ID

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9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12943-017-0748-y

PMC publication ID

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Europe PubMed Central

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7 April 2020

PubMed publication ID

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7 April 2020

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