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Emerging roles of PKM2 in cell metabolism and cancer progression
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scholarly article
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Europe PubMed Central
PMCID
3466350
retrieved
13 August 2017
title
Emerging roles of PKM2 in cell metabolism and cancer progression
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3466350
retrieved
13 August 2017
author
Gregg L. Semenza
series ordinal
2
object named as
Gregg L Semenza
1 reference
stated in
Europe PubMed Central
retrieved
13 August 2017
PMCID
3466350
author name string
Weibo Luo
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3466350
retrieved
13 August 2017
publication date
21 July 2012
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stated in
Europe PubMed Central
PMCID
3466350
retrieved
13 August 2017
published in
Trends in Endocrinology and Metabolism
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stated in
Europe PubMed Central
PMCID
3466350
retrieved
13 August 2017
volume
23
1 reference
stated in
Europe PubMed Central
PMCID
3466350
retrieved
13 August 2017
issue
11
1 reference
stated in
Europe PubMed Central
PMCID
3466350
retrieved
13 August 2017
page(s)
560-566
1 reference
stated in
Europe PubMed Central
PMCID
3466350
retrieved
13 August 2017
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Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
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PPARγ contributes to PKM2 and HK2 expression in fatty liver
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Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase
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Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression
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Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
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Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons
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Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells
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No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis
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Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase
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Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells
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Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.
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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
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Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2.
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Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
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The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
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Cellular metabolic stress: considering how cells respond to nutrient excess.
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Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells
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Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice
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The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism
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Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
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Identification of small molecule inhibitors of pyruvate kinase M2
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30 September 2017
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
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30 September 2017
HIF-1: upstream and downstream of cancer metabolism
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30 September 2017
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
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30 September 2017
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30 September 2017
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30 September 2017
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30 September 2017
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
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PubMed Central
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30 September 2017
Pyruvate kinase M2 is a phosphotyrosine-binding protein
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Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein
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Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription
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Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
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HIF-1 mediates the Warburg effect in clear cell renal carcinoma
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30 September 2017
Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase.
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30 September 2017
Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death
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30 September 2017
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
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30 September 2017
Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays
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30 September 2017
On the Origin of Cancer Cells
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30 September 2017
Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation
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30 September 2017
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
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30 September 2017
Alterations in glucose metabolism in chick-embryo cells transformed by Rous sarcoma virus: intracellular levels of glycolytic intermediates
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30 September 2017
The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing
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Production of large amounts of hydrogen peroxide by human tumor cells
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30 September 2017
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
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30 September 2017
Reversion of transformed glycolysis to normal by inhibition of protein synthesis in rat kidney cells infected with temperature-sensitive mutant of Rous sarcoma virus
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30 September 2017
Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins
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30 September 2017
Systemic elevation of PTEN induces a tumor-suppressive metabolic state
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29 June 2018
Coenzyme factor-a new oxidation catalyst
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29 June 2018
Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element
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Multimolecular forms of pyruvate kinase from rat and other mammalian tissues. I. Electrophoretic studies.
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29 June 2018
Glycolysis in chick embryo cell cultures transformed by Rous sarcoma virus
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29 June 2018
The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters.
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29 June 2018
The pentose phosphate pathway is a metabolic redox sensor and regulates transcription during the antioxidant response.
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22 September 2018
The SUMO-E3 ligase PIAS3 targets pyruvate kinase M2.
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22 September 2018
Identifiers
DOI
10.1016/J.TEM.2012.06.010
1 reference
stated in
Europe PubMed Central
PMCID
3466350
retrieved
13 August 2017
PMCID
3466350
1 reference
stated in
Europe PubMed Central
PMCID
3466350
retrieved
13 August 2017
PubMed ID
22824010
1 reference
stated in
Europe PubMed Central
PMCID
3466350
retrieved
13 August 2017
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