(Q24603549)

2

0 references

Jianhui Ma

3

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Haiyong Peng

4

0 references

Fang Wang

5

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Xiaojun Zha

6

0 references

Yanan Wang

7

0 references

Yanling Jing

8

0 references

Hongwang Yang

9

0 references

Rongrong Chen

10

0 references

Long Chang

11

0 references

Yu Zhang

12

0 references

June Goto

13

0 references

Hiroaki Onda

14

0 references

Tong Chen

15

0 references

Ming-Rong Wang

16

0 references

Youyong Lu

17

0 references

Han You

18

0 references

David Kwiatkowski

19

0 references

Hongbing Zhang

Proceedings of the National Academy of Sciences of the United States of America

20

0 references

language of work or name

English

0 references

publication date

8 March 2011

0 references

published in

0 references

volume

108

0 references

issue

10

0 references

page(s)

4129-34

0 references

cites work

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Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

7 April 2017

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

7 April 2017

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7 April 2017

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Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

7 April 2017

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

22 April 2017

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Cancer cell metabolism: Warburg and beyond

7 April 2017

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

7 April 2017

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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

7 April 2017

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

7 April 2017

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

7 April 2017

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

7 April 2017

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

7 April 2017

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The tuberous sclerosis complex

7 April 2017

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Akt stimulates aerobic glycolysis in cancer cells

7 April 2017

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Akt regulates growth by directly phosphorylating Tsc2

7 April 2017

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Evidence for an alternative glycolytic pathway in rapidly proliferating cells

7 April 2017

1 reference

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PTEN loss accelerates KrasG12D-induced pancreatic cancer development

27 September 2017

1 reference

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Phospholipase D-mTOR requirement for the Warburg effect in human cancer cells

27 September 2017

1 reference

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Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases

27 September 2017

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A therapeutic role for targeting c-Myc/Hif-1-dependent signaling pathways

27 September 2017

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FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1.

27 September 2017

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Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

27 September 2017

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The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

27 September 2017

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Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

27 September 2017

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

27 September 2017

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An emerging role of mTOR in lipid biosynthesis.

27 September 2017

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mTOR and cancer: many loops in one pathway.

27 September 2017

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An essential role of the HIF-1alpha-c-Myc axis in malignant progression

27 September 2017

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Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose

27 September 2017

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A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles

27 September 2017

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Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2.

27 September 2017

1 reference

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The role of PTEN signaling perturbations in cancer and in targeted therapy

27 September 2017

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The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey

27 September 2017

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Tenets of PTEN tumor suppression

27 September 2017

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Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

HIF-1 mediates the Warburg effect in clear cell renal carcinoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

Metabolic targeting as an anticancer strategy: dawn of a new era?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-alpha/Sima

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

The interplay between MYC and HIF in cancer.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3054028

28 November 2018

Identifiers

DOI

10.1073/PNAS.1014769108

1 reference

900103

ADS bibcode

2011PNAS..108.4129S

0 references

900103

1 reference

1 reference

1 reference