(Q37270446)

19 August 2017

1 reference

title

The role of PTEN signaling perturbations in cancer and in targeted therapy (English)

1 reference

19 August 2017

M Keniry

1

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19 August 2017

R Parsons

series ordinal

2

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19 August 2017

language of work or name

English

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publication date

1 September 2008

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19 August 2017

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19 August 2017

volume

27

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19 August 2017

issue

41

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19 August 2017

page(s)

5477-5485

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Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity

19 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

21 January 2018

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PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers

21 January 2018

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FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

21 January 2018

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Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

31 March 2020

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.248

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PTEN enters the nuclear age.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Mutation of the PIK3CA gene in ovarian and breast cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.248

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Membrane-binding and activation mechanism of PTEN.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Nuclear Ptdlns(3,4,5)P3 signaling: an ongoing story

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Pten is essential for embryonic development and tumour suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PTEN mutations in gliomas and glioneuronal tumors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Analysis of PTEN and the 10q23 region in primary prostate carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Binding and phosphorylation of par-4 by akt is essential for cancer cell survival.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Temporal and spatial regulation of chemotaxis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

DJ-1, a novel regulator of the tumor suppressor PTEN.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

An epidermal growth factor receptor/Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic acid.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Reversible inactivation of the tumor suppressor PTEN by H2O2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Mechanistic insights into maintenance of high p53 acetylation by PTEN.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PTEN enters the nucleus by diffusion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Rheb binds and regulates the mTOR kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

AKT/PKB signaling: navigating downstream

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Germline mutations in PTEN are present in Bannayan-Zonana syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PCAF modulates PTEN activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Colorectal cancer: mutations in a signalling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Akt regulates growth by directly phosphorylating Tsc2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Lack of PTEN sequesters CHK1 and initiates genetic instability.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,N0) prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

High frequency of mutations of the PIK3CA gene in human cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Essential role for nuclear PTEN in maintaining chromosomal integrity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Regulation of PTEN transcription by p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Evidence that a phosphatidylinositol 3,4,5-trisphosphate-binding protein can function in nucleus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Identification of a tumour suppressor network opposing nuclear Akt function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Ubiquitination regulates PTEN nuclear import and tumor suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Phosphorylation of the PTEN tail regulates protein stability and function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Genomic activation of the EGFR and HER2-neu genes in a significant proportion of invasive epithelial ovarian cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21 WAF-induced differentiation triggered by GSK3beta inactivation and reduced AKT activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.248

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.248

1 reference

Dimensions Publication ID

19 August 2017

1041697415

0 references

Fatcat ID

release_wkqveudgljeqfg46i5s5rc5ppe

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/wkqveudgljeqfg46i5s5rc5ppe

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference