(Q24307524)

GOA release 2020-03-11

author

Kari Alitalo

9

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Gordon Stamp

8

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Julian Downward

10

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Yihua Wang

object named as

Yihua Wang

4

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author name string

Surbhi Gupta

1

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Antoine R Ramjaun

2

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Paula Haiko

3

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Patricia H Warne

5

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Barbara Nicke

6

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Emma Nye

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases

7

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language of work or name

English

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publication date

1 June 2007

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published in

Cell

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volume

129

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issue

5

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page(s)

957-68

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cites work

1 reference

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Mechanism of activation of protein kinase B by insulin and IGF-1

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Signaling by distinct classes of phosphoinositide 3-kinases

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Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

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Somatic alterations in the human cancer genome

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RalGDS is required for tumor formation in a model of skin carcinogenesis.

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Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation.

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Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?

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Signalling by PI3K isoforms: insights from gene-targeted mice.

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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Activation of phosphoinositide 3-kinase gamma by Ras.

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Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

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Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

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Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

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Tumour biology: senescence in premalignant tumours

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Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

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Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.

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Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

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Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

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Input from Ras is required for maximal PI(3)K signalling in Drosophila

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Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils

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Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

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Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

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Targeting RAS signalling pathways in cancer therapy

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The RAF proteins take centre stage

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Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation

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7 January 2021

The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

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Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

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Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

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7 January 2021

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

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Analysis of the transcriptional program induced by Raf in epithelial cells

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Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing

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Cardiovascular failure in mouse embryos deficient in VEGF receptor-3

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7 January 2021

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

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Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.

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7 January 2021

Atypical adenomatous hyperplasia of the lung: a clinicopathological study of 118 cases including cases with multiple atypical adenomatous hyperplasia

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7 January 2021

Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development

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7 January 2021

The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway

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7 January 2021

Evaluation and management of chylous ascites

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