(Q47305917)

English

Therapeutic Delivery of Simvastatin Loaded in PLA-PEG Polymersomes Resulted in Amplification of Anti-inflammatory Effects in Activated Microglia.

scientific article published on 14 December 2017

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scholarly article

1 reference

Europe PubMed Central

13 January 2018

http://europepmc.org/abstract/MED/29243172

Therapeutic Delivery of Simvastatin Loaded in PLA-PEG Polymersomes Resulted in Amplification of Anti-inflammatory Effects in Activated Microglia. (English)

1 reference

Europe PubMed Central

13 January 2018

http://europepmc.org/abstract/MED/29243172

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1 reference

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Moses O Oyewumi

object named as

Moses O Oyewumi

3

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author name string

Dharani Manickavasagam

1

1 reference

Europe PubMed Central

13 January 2018

http://europepmc.org/abstract/MED/29243172

Kimberly Novak

2

1 reference

Europe PubMed Central

13 January 2018

http://europepmc.org/abstract/MED/29243172

language of work or name

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publication date

14 December 2017

1 reference

Europe PubMed Central

13 January 2018

http://europepmc.org/abstract/MED/29243172

The AAPS Journal

1 reference

Europe PubMed Central

13 January 2018

http://europepmc.org/abstract/MED/29243172

20

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Europe PubMed Central

13 January 2018

http://europepmc.org/abstract/MED/29243172

18

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Europe PubMed Central

13 January 2018

http://europepmc.org/abstract/MED/29243172

1

1 reference

Europe PubMed Central

13 January 2018

http://europepmc.org/abstract/MED/29243172

https://scigraph.springernature.com/pub.10.1208/s12248-017-0176-3

0 references

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymersomes: Tough Vesicles Made from Diblock Copolymers

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia: phagocyte and glia cell.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biodegradable polymersomes as a basis for artificial cells: encapsulation, release and targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polystyrene-b-poly(acrylic acid) vesicle size control using solution properties and hydrophilic block length

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

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Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-assembled poly(butadiene)-b-poly(ethylene oxide) polymersomes as paclitaxel carriers

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated microglia in primary MS lesions: defenders or aggressors?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymersome carriers: from self-assembly to siRNA and protein therapeutics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simvastatin reduces secondary brain injury caused by cortical contusion in rats: possible involvement of TLR4/NF-kappaB pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simvastatin attenuates microglial cells and astrocyte activation and decreases interleukin-1beta level after traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of microglia on the pathogenesis of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline reduces astrocytic reactivation and neuroinflammation in the hippocampus of a vascular cognitive impairment rat model

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statins: multiple neuroprotective mechanisms in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone marrow-derived mesenchymal stem cells modulate BV2 microglia responses to lipopolysaccharide

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flavopiridol protects against inflammation by attenuating leukocyte-endothelial interaction via inhibition of cyclin-dependent kinase 9

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self assembling polymers as polymersomes for drug delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiology of microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Self-Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective CDK inhibitor limits neuroinflammation and progressive neurodegeneration after brain trauma

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymersomes for drug delivery: design, formation and characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biodegradable polymersomes as carriers and release systems for paclitaxel using Oregon Green® 488 labeled paclitaxel as a model compound

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biocompatibility, efficacy and biodistribution of Gelucire-stabilized nanoparticles engineered for docetaxel delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statin use and risk of Parkinson's disease: a meta-analysis of observational studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solubility enhancement of simvastatin: a review.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simvastatin attenuates axonal injury after experimental traumatic brain injury and promotes neurite outgrowth of primary cortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The changing phenotype of microglia from homeostasis to disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statins in the prevention of dementia and Alzheimer's disease: a meta-analysis of observational studies and an assessment of confounding

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biocompatibility and in vivo tolerability of a new class of photoresponsive alkoxylphenacyl-based polycarbonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progesterone protective effects in neurodegeneration and neuroinflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline alleviates beta-amyloid protein and tau pathology via restraining neuroinflammation induced by diabetic metabolic disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinated role of voltage-gated sodium channels and the Na+/H+ exchanger in sustaining microglial activation during inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microglia actions in Alzheimer’s disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of statins in the treatment of multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multifunctional polymersomes for cytosolic delivery of gemcitabine and doxorubicin to cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formulation and photoirradiation parameters that influenced photoresponsive drug delivery using alkoxylphenacyl-based polycarbonates

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statin treatment affects cytokine release and phagocytic activity in primary cultured microglia through two separable mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contributory roles of innate properties of cetyl alcohol/gelucire nanoparticles to antioxidant and anti-inflammation activities of quercetin

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline Attenuates Neonatal Germinal-Matrix-Hemorrhage-Induced Neuroinflammation and Brain Edema by Activating Cannabinoid Receptor 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymersome-based drug-delivery strategies for cancer therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rosiglitazone, a Peroxisome Proliferator-Activated Receptor (PPAR)-γ Agonist, Attenuates Inflammation Via NF-κB Inhibition in Lipopolysaccharide-Induced Peritonitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rosuvastatin enhances anti-inflammatory and inhibits pro-inflammatory functions in cultured microglial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of alkoxylphenacyl-based polycarbonates as a potential platform for controlled delivery of a model anti-glaucoma drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PPAR-α Agonist WY-14643 Inhibits LPS-Induced Inflammation in Synovial Fibroblasts via NF-kB Pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early Minocycline and Late FK506 Treatment Improves Survival and Alleviates Neuroinflammation, Neurodegeneration, and Behavioral Deficits in Prion-Infected Hamsters

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug delivery to the brain: how can nanoencapsulated statins be used in the clinic?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29243172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1208/S12248-017-0176-3

1 reference

Europe PubMed Central

13 January 2018

http://europepmc.org/abstract/MED/29243172

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0 references

1 reference

Europe PubMed Central

13 January 2018

http://europepmc.org/abstract/MED/29243172

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