(Q47306135)

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Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit

scientific article published on 21 November 2017

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scholarly article

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Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/29158578

Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit (English)

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PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/29158578

synaptic plasticity

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based on heuristic

inferred from title

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10 June 2020

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10 June 2020

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N Yao

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10 June 2020

X Zhang

3

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10 June 2020

P Svenningsson

4

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10 June 2020

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21 November 2017

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13 January 2018

http://europepmc.org/abstract/MED/29158578

Molecular Psychiatry

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10 June 2020

23

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10 June 2020

10

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10 June 2020

2066-2077

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10 June 2020

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Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

21 November 2017

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0 references

https://scigraph.springernature.com/pub.10.1038/mp.2017.239

0 references

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Ketamine: translating mechanistic discoveries into the next generation of glutamate modulators for mood disorders

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Antidepressant mechanism of ketamine: perspective from preclinical studies

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Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors

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NMDAR inhibition-independent antidepressant actions of ketamine metabolites.

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The role of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in depression: central mediators of pathophysiology and antidepressant activity?

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(R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine.

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How does ketamine elicit a rapid antidepressant response?

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KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID-ACTING ANTIDEPRESSANTS.

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Activation of a ventral hippocampus-medial prefrontal cortex pathway is both necessary and sufficient for an antidepressant response to ketamine

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The action of antidepressants on the glutamate system: regulation of glutamate release and glutamate receptors.

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Bidirectional synaptic plasticity: from theory to reality

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The brain reward circuitry in mood disorders

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The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder

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R (-)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine

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R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

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NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

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Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants

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Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study

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21 January 2018

NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A1 receptors: evidence from knockout mice.

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21 January 2018

Allosteric modulation of GluN2C/GluN2D-containing NMDA receptors bidirectionally modulates dopamine release: implication for Parkinson's disease

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21 January 2018

Dopamine depletion of the striatum causes a cell-type specific reorganization of GluN2B- and GluN2D-containing NMDA receptors.

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21 January 2018

The GABAA receptor agonist muscimol induces an age- and region-dependent form of long-term depression in the mouse striatum.

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21 January 2018

Long-term potentiation in the nucleus accumbens requires both NR2A- and NR2B-containing N-methyl-D-aspartate receptors

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21 January 2018

Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens

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21 January 2018

Effects of Ketamine and Ketamine Metabolites on Evoked Striatal Dopamine Release, Dopamine Receptors, and Monoamine Transporters.

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21 January 2018

Lack of effect of chronic ketamine administration on depression-like behavior and frontal cortex autophagy in female and male ICR mice.

1 reference

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21 January 2018

Dopamine induces a GluN2A-dependent form of long-term depression of NMDA synaptic responses in the nucleus accumbens.

1 reference

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21 January 2018

NMDA receptor function: subunit composition versus spatial distribution

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NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

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21 January 2018

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

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21 January 2018

Signaling pathways underlying the rapid antidepressant actions of ketamine

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(R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function.

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21 January 2018

Differential regulation of GluA1 expression by ketamine and memantine.

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21 January 2018

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

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A recollection of mTOR signaling in learning and memory

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Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex

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Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation.

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Regulation of protein kinase Mzeta synthesis by multiple kinases in long-term potentiation.

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AMPARs and synaptic plasticity: the last 25 years

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Extensive phosphorylation of AMPA receptors in neurons

1 reference

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Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress

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Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli

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Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system

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Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience

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Ventral tegmental area glutamate neurons: electrophysiological properties and projections

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Glutamatergic and dopaminergic neurons in the mouse ventral tegmental area.

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Essential roles of AMPA receptor GluA1 phosphorylation and presynaptic HCN channels in fast-acting antidepressant responses of ketamine

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NMDA receptor-mediated mechanism of ketamine-induced facilitation of glutamatergic excitatory synaptic transmission

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Inhalation anaesthetics block accommodation of pyramidal cell discharge in the rat hippocampus.

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Acute suppression of spontaneous neurotransmission drives synaptic potentiation

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Metaplastic effects of subanesthetic ketamine on CA1 hippocampal function

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Clinically relevant concentrations of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse facilitation in mouse hippocampal slices

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Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation

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Restoring mood balance in depression: ketamine reverses deficit in dopamine-dependent synaptic plasticity

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The Rapidly Acting Antidepressant Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Rapidly Engage Dopaminergic Mood Circuits

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Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function

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The stability of NR2B in the nucleus accumbens controls behavioral and synaptic adaptations to chronic stress

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mGluRs induce a long-term depression in the ventral tegmental area that involves a switch of the subunit composition of AMPA receptors

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Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

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Anatomical substrates for glutamate-dopamine interactions: evidence for specificity of connections and extrasynaptic actions

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Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses

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Long-lasting changes in hippocampal synaptic plasticity and cognition in an animal model of NMDA receptor dysfunction in psychosis

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Phenotype of mice with inducible ablation of GluA1 AMPA receptors during late adolescence: relevance for mental disorders

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Impact of adolescent GluA1 AMPA receptor ablation in forebrain excitatory neurons on behavioural correlates of mood disorders

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GSK-3: A key regulatory target for ketamine's rapid antidepressant effects mediated by enhanced AMPA to NMDA throughput

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Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

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NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum.

1 reference

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7 January 2021

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10.1038/MP.2017.239

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29158578%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29158578%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

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