(Q47318878)

English

Evolutionary basis of a new gene- and immune-therapeutic approach for the treatment of malignant brain tumors: from mice to clinical trials for glioma patients

scientific article published on 15 July 2017

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/28720549

Evolutionary basis of a new gene- and immune-therapeutic approach for the treatment of malignant brain tumors: from mice to clinical trials for glioma patients (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/28720549

1 reference

based on heuristic

1 reference

based on heuristic

author name string

Pedro R Lowenstein

1

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/28720549

Maria G Castro

2

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/28720549

publication date

15 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/28720549

Clinical Immunology

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/28720549

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

What is the blood-brain barrier (not)?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

What is immune privilege (not)?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Surgery for malignant gliomas: mechanistic reasoning and slippery statistics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Systemic immune deficiency necessary for cytomegalovirus invasion of the mature brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Immunology of viral-vector-mediated gene transfer into the brain: an evolutionary and developmental perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Strong promoters are the key to highly efficient, noninflammatory and noncytotoxic adenoviral-mediated transgene delivery into the brain in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Persistent pathogens in the parenchyma of the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for ch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Cytomegalovirus cell tropism, replication, and gene transfer in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Pathology of cerebrospinal fluid and interstitial fluid of the CNS: significance for Alzheimer disease, prion disorders and multiple sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Long-term persistence of activated cytotoxic T lymphocytes after viral infection of the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Bacillus Calmette-Guérin sequestered in the brain parenchyma escapes immune recognition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Recruitment, activation and proliferation of CD8+ memory T cells in an immunoprivileged site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Protection against influenza virus encephalitis by adoptive lymphocyte transfer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Immune responses to adenoviral vectors during gene transfer in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

The immunogenicity of intracerebral virus infection depends on anatomical site.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Immune responses to adenovirus vectors in the nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Lymphocyte targeting of the central nervous system: a review of afferent and efferent CNS-immune pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Overriding the brain's intrinsic resistance to leukocyte recruitment with intraparenchymal injections of recombinant chemokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Delayed-type hypersensitivity lesions in the central nervous system are prevented by inhibitors of matrix metalloproteinases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Role of T cells in inflammation caused by adenovirus vectors in the brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Immunological instability of persistent adenovirus vectors in the brain: peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Immunological consequences of HSV-1-mediated gene transfer into the CNS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Anatomical pathways for lymphatic drainage of the brain and their pathological significance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

Pathways of fluid drainage from the brain--morphological aspects and immunological significance in rat and man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5768465

2 November 2018

CSF drains directly from the subarachnoid space into nasal lymphatics in the rat. Anatomy, histology and immunological significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/28720549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DCVax-Brain and DC vaccines in the treatment of GBM

1 reference

https://pubmed.ncbi.nlm.nih.gov/28720549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenovirus gene transfer causes inflammation in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/28720549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bevacizumab for newly diagnosed glioblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/28720549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The case for immunosuppression in clinical gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/28720549

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CLIM.2017.07.006

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/28720549

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/28720549

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