(Q47381323)

26 June 2018

title

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease (English)

1 reference

26 June 2018

0 references

Jay Rasmussen

1

0 references

Diego Sepulveda-Falla

Diego Sepulveda-Falla

12

0 references

Markus Glatzel

Markus Glatzel

13

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Lary C. Walker

Lary C Walker

19

0 references

Kaj Blennow

9

Kaj Blennow

1 reference

26 June 2018

8

Erik Portelius

1 reference

26 June 2018

Mathias Jucker

20

Mathias Jucker

1 reference

26 June 2018

Matthias Staufenbiel

18

Matthias Staufenbiel

1 reference

26 June 2018

Adrian L. Oblak

14

Adrian L Oblak

1 reference

26 June 2018

Tammaryn Lashley

10

Tammaryn Lashley

1 reference

26 June 2018

Bernardino F. Ghetti

15

Bernardino Ghetti

1 reference

26 June 2018

author name string

Jasmin Mahler

2

1 reference

26 June 2018

Natalie Beschorner

3

1 reference

26 June 2018

Stephan A Kaeser

4

1 reference

26 June 2018

Lisa M Häsler

5

1 reference

26 June 2018

Frank Baumann

6

1 reference

26 June 2018

Sofie Nyström

7

1 reference

26 June 2018

Nick C Fox

11

1 reference

26 June 2018

K Peter R Nilsson

16

1 reference

26 June 2018

Per Hammarström

17

1 reference

26 June 2018

language of work or name

English

0 references

publication date

20 November 2017

1 reference

26 June 2018

Proceedings of the National Academy of Sciences of the United States of America

published in

1 reference

26 June 2018

volume

114

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26 June 2018

issue

49

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26 June 2018

page(s)

13018-13023

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26 June 2018

Aβ propagation and strains: Implications for the phenotypic diversity in Alzheimer's disease

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1 reference

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30 June 2018

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Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

30 June 2018

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Nanoscale Structure and Spectroscopic Probing of Aβ1-40 Fibril Bundle Formation

30 June 2018

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Proteopathic Strains and the Heterogeneity of Neurodegenerative Diseases.

30 June 2018

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Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series

30 June 2018

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Anionic Oligothiophenes Compete for Binding of X-34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain-Derived Aβ.

30 June 2018

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Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue

30 June 2018

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Peptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM.

30 June 2018

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Structure-based drug design identifies polythiophenes as antiprion compounds

30 June 2018

1 reference

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Distinct Spacing Between Anionic Groups: An Essential Chemical Determinant for Achieving Thiophene-Based Ligands to Distinguish β-Amyloid or Tau Polymorphic Aggregates

30 June 2018

1 reference

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Amyloid polymorphism: structural basis and neurobiological relevance

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Aβ(1-42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Rapidly progressive Alzheimer's disease features distinct structures of amyloid-β.

30 June 2018

1 reference

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Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients

30 June 2018

1 reference

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Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Purified and synthetic Alzheimer's amyloid beta (Aβ) prions

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

The amyloid state of proteins in human diseases

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer's disease

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Darwinian evolution of prions in cell culture

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Characterization of amyloid beta peptides in cerebrospinal fluid by an automated immunoprecipitation procedure followed by mass spectrometry

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

The development of amyloid beta protein deposits in the aged brain.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by beta protein immunostaining.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Morphology and distribution of plaque and related deposits in the brains of Alzheimer's disease and control cases. An immunohistochemical study using amyloid beta-protein antibody.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Fibril structure of amyloid-β(1-42) by cryo-electron microscopy.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Spectral discrimination of cerebral amyloid lesions after peripheral application of luminescent conjugated oligothiophenes.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Mapping the road forward in Alzheimer's disease

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5724274

14 August 2018

Identifiers

DOI

10.1073/PNAS.1713215114

1 reference

26 June 2018

PMCID

5724274

1 reference

26 June 2018

PubMed ID

29158413

1 reference

26 June 2018