(Q47431945)

16 January 2018

title

Evidence for M1-Linked Polyubiquitin-Mediated Conformational Change in NEMO. (English)

1 reference

16 January 2018

author name string

Arthur V Hauenstein

1

1 reference

16 January 2018

Guozhou Xu

2

1 reference

16 January 2018

Venkataraman Kabaleeswaran

3

1 reference

16 January 2018

Hao Wu

4

1 reference

16 January 2018

language of work or name

English

0 references

publication date

27 October 2017

1 reference

16 January 2018

Journal of Molecular Biology

number of pages

8

1 reference

based on heuristic

inferred from page(s)

published in

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16 January 2018

volume

429

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16 January 2018

issue

24

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16 January 2018

page(s)

3793-3800

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16 January 2018

30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology

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26 August 2018

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Polyubiquitin Drives the Molecular Interactions of the NF-κB Essential Modulator (NEMO) by Allosteric Regulation.

26 August 2018

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A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation

26 August 2018

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Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.

26 August 2018

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26 August 2018

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Preparation of distinct ubiquitin chain reagents of high purity and yield.

26 August 2018

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Crystal structure of inhibitor of κB kinase β

26 August 2018

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DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

26 August 2018

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Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin

26 August 2018

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

26 August 2018

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Structural Basis for Recognition of Diubiquitins by NEMO

26 August 2018

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The zinc finger of NEMO is a functional ubiquitin-binding domain

26 August 2018

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Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome

26 August 2018

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Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site

26 August 2018

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Alterations of the IKBKG locus and diseases: an update and a report of 13 novel mutations

26 August 2018

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NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex

26 August 2018

1 reference

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Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

26 August 2018

1 reference

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A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation

26 August 2018

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Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation

26 August 2018

1 reference

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Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

26 August 2018

1 reference

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Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5705538

Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5705538

NEMO trimerizes through its coiled-coil C-terminal domain

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5705538

Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation

26 August 2018

1 reference

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Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex

26 August 2018

1 reference

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

26 August 2018

1 reference

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Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5705538

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5705538

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5705538

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5705538

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5705538

Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5705538

10.1016/J.JMB.2017.10.026

26 August 2018

Identifiers

DOI

1 reference

16 January 2018

0 references

1 reference

16 January 2018