(Q47438129)

16 January 2018

title

Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin (English)

1 reference

16 January 2018

author name string

Laura Rozan

1

1 reference

16 January 2018

Damian J Krysan

2

1 reference

16 January 2018

Nathan C Rockwell

3

1 reference

16 January 2018

Robert S Fuller

4

1 reference

16 January 2018

language of work or name

English

0 references

publication date

24 May 2004

1 reference

16 January 2018

Journal of Biological Chemistry

published in

1 reference

16 January 2018

volume

279

1 reference

16 January 2018

issue

34

1 reference

16 January 2018

page(s)

35656-35663

1 reference

16 January 2018

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

A look at the Caenorhabditis elegans Kex2/Subtilisin-like proprotein convertase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Subtilase-like pro-protein convertases: from molecular specificity to therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

On the size of the active site in proteases. I. Papain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Internally consistent libraries of fluorogenic substrates demonstrate that Kex2 protease specificity is generated by multiple mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Structural and enzymatic characterization of a purified prohormone-processing enzyme: secreted, soluble Kex2 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Interplay between S1 and S4 subsites in Kex2 protease: Kex2 exhibits dual specificity for the P4 side chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Differential utilization of enzyme-substrate interactions for acylation but not deacylation during the catalytic cycle of Kex2 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Direct measurement of acylenzyme hydrolysis demonstrates rate-limiting deacylation in cleavage of physiological sequences by the processing protease Kex2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin. Generation of a potent inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Mutational replacements in subtilisin 309. Val104 has a modulating effect on the P4 substrate preference

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Display of active subtilisin 309 on phage: analysis of parameters influencing the selection of subtilisin variants with changed substrate specificity from libraries using phosphonylating inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Designing Subtilisin BPN' To Cleave Substrates Containing Dibasic Residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Furilisin: a variant of subtilisin BPN' engineered for cleaving tribasic substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Crystal and molecular structure of chymotrypsin inhibitor 2 from barley seeds in complex with subtilisin Novo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Subtilases: the superfamily of subtilisin-like serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

The crystal structure of the proprotein processing proteinase furin explains its stringent specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

One-step site-directed mutagenesis of the Kex2 protease oxyanion hole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

Structural plasticity broadens the specificity of an engineered protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

In vitro characterization of the novel proprotein convertase PC7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

MOLMOL: a program for display and analysis of macromolecular structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

[11] Biochemical and genetic methods for analyzing specificity and activity of a precursor-processing enzyme: Yeast Kex2 protease, kexin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M405362200

21 January 2018

Identifiers

DOI

10.1074/JBC.M405362200

1 reference

16 January 2018

1 reference

16 January 2018