(Q47564225)

4 February 2018

http://europepmc.org/abstract/MED/29180608

title

t-Darpp Activates IGF-1R Signaling to Regulate Glucose Metabolism in Trastuzumab-Resistant Breast Cancer Cells (English)

1 reference

4 February 2018

http://europepmc.org/abstract/MED/29180608

author

Markus Kalkum

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Gal Lenz

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Angelica Hamilton

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Shuhui Geng

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Teresa Hong

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Jamil Momand

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Susan E Kane

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Janice M Huss

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

language of work or name

English

0 references

publication date

27 November 2017

1 reference

4 February 2018

http://europepmc.org/abstract/MED/29180608

published in

Clinical Cancer Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

1216-1226

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

Mechanism of insulin and IGF-I receptor activation and signal transduction specificity. Receptor dimer cross-linking, bell-shaped curves, and sustained versus transient signaling

10 June 2020

cites work

1 reference

12 December 2020

Expression of the insulin-like growth factor 1 receptor (IGF-1R) in breast cancer cells: evidence for a regulatory role of dolichyl phosphate in the transition from an intracellular to an extracellular IGF-1 pathway

1 reference

12 December 2020

Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

1 reference

12 December 2020

Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP

1 reference

12 December 2020

On the Origin of Cancer Cells

1 reference

12 December 2020

Overexpression of the 32‐kilodalton dopamine and cyclic adenosine 3′,5′‐monophosphate‐regulated phosphoprotein in common adenocarcinomas

1 reference

12 December 2020

Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors

1 reference

12 December 2020

Darpp-32: a novel antiapoptotic gene in upper gastrointestinal carcinomas

1 reference

12 December 2020

Insulin-like growth factor-1 receptor (IGF-1R) expression does not predict for resistance to trastuzumab-based treatment in patients with Her-2/neu overexpressing metastatic breast cancer

1 reference

12 December 2020

Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells

1 reference

12 December 2020

Glycolysis inhibition for anticancer treatment

1 reference

12 December 2020

Disrupting insulin-like growth factor signaling as a potential cancer therapy

1 reference

12 December 2020

The EGF receptor interacts with the type 1 IGF receptor and regulates its stability

1 reference

12 December 2020

Trastuzumab: triumphs and tribulations

1 reference

12 December 2020

An Investigation of the Ligand Binding Properties and Negative Cooperativity of Soluble Insulin-like Growth Factor Receptors

1 reference

12 December 2020

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

1 reference

12 December 2020

t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism

1 reference

12 December 2020

Insulin, insulin-like growth factors, insulin resistance, and neoplasia

1 reference

12 December 2020

Brick by brick: metabolism and tumor cell growth

1 reference

12 December 2020

Causes and consequences of increased glucose metabolism of cancers

1 reference

12 December 2020

Expression of t-DARPP mediates trastuzumab resistance in breast cancer cells

1 reference

12 December 2020

Insulin, insulin-like growth factors and neoplasia

1 reference

12 December 2020

IGF and insulin receptor signaling in breast cancer.

1 reference

12 December 2020

Both t-Darpp and DARPP-32 can cause resistance to trastuzumab in breast cancer cells and are frequently expressed in primary breast cancers.

1 reference

12 December 2020

Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression

1 reference

12 December 2020

Darpp-32 and its truncated variant t-Darpp have antagonistic effects on breast cancer cell growth and herceptin resistance

1 reference

12 December 2020

Lapatinib: a review of its use in the treatment of HER2-overexpressing, trastuzumab-refractory, advanced or metastatic breast cancer

1 reference

12 December 2020

Cancer's insatiable appetite

1 reference

12 December 2020

Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell lines

1 reference

12 December 2020

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

1 reference

12 December 2020

The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines

1 reference

12 December 2020

t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer

1 reference

12 December 2020

Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism.

1 reference

12 December 2020

Insulin-like growth factor receptor (IGF-1R) in breast cancer subtypes.

1 reference

12 December 2020

Molecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast Cancer

1 reference

12 December 2020

Increased signalling of EGFR and IGF1R, and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas.

1 reference

12 December 2020

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

1 reference

12 December 2020

The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

1 reference

12 December 2020

Regulation of ERBB2 receptor by t-DARPP mediates trastuzumab resistance in human esophageal adenocarcinoma

1 reference

12 December 2020

The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells

1 reference

12 December 2020

Molecular Mechanisms of Trastuzumab-Based Treatment in HER2-Overexpressing Breast Cancer

1 reference

12 December 2020

Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer

1 reference

12 December 2020

Insulin-like growth factor (IGF) signaling in tumorigenesis and the development of cancer drug resistance

1 reference

12 December 2020

t-Darpp Promotes Enhanced EGFR Activation and New Drug Synergies in Her2-Positive Breast Cancer Cells

1 reference

12 December 2020

A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway

1 reference

12 December 2020

10.1158/1078-0432.CCR-17-0824

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29180608%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference