(Q47626622)

4 February 2018

title

Evaluation of the Selectivity and Cysteine Dependence of Inhibitors across the Regulator of G Protein-Signaling Family (English)

1 reference

4 February 2018

author name string

Michael P Hayes

series ordinal

1

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4 February 2018

Christopher R Bodle

series ordinal

2

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4 February 2018

David L Roman

series ordinal

3

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4 February 2018

publication date

19 October 2017

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4 February 2018

published in

Molecular Pharmacology

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4 February 2018

volume

93

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4 February 2018

issue

1

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4 February 2018

page(s)

25-35

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4 February 2018

Development of a bimolecular luminescence complementation assay for RGS: G protein interactions in cells

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Intrathecal RGS4 inhibitor, CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test

26 August 2018

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5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19.

26 August 2018

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Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay

26 August 2018

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A high throughput screen for RGS proteins using steady state monitoring of free phosphate formation

26 August 2018

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Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transduction

26 August 2018

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A unique role of RGS9-2 in the striatum as a positive or negative regulator of opiate analgesia

26 August 2018

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26 August 2018

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Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins

26 August 2018

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26 August 2018

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RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects.

26 August 2018

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Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986

26 August 2018

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Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent

26 August 2018

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26 August 2018

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Polyplexed flow cytometry protein interaction assay: a novel high-throughput screening paradigm for RGS protein inhibitors

26 August 2018

1 reference

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A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screen

26 August 2018

1 reference

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Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells

26 August 2018

1 reference

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Structural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunits

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708088

The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708088

Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708088

Return of the GDI: the GoLoco motif in cell division.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708088

RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708088

Differential effects of regulator of G protein signaling (RGS) proteins on serotonin 5-HT1A, 5-HT2A, and dopamine D2 receptor-mediated signaling and adenylyl cyclase activity

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708088

Structure-based design, synthesis, and pharmacologic evaluation of peptide RGS4 inhibitors.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708088

RGS9 modulates dopamine signaling in the basal ganglia

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708088

Endogenous RGS protein action modulates mu-opioid signaling through Galphao. Effects on adenylyl cyclase, extracellular signal-regulated kinases, and intracellular calcium pathways

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708088

Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708088

RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708088

The A326S mutant of Gialpha1 as an approximation of the receptor-bound state

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708088

GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5708088

Potent and selective inhibition of angiotensin AT1 receptor signaling by RGS2: roles of its N-terminal domain

26 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29051318

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/MOL.117.109843

1 reference

4 February 2018

0 references

1 reference

4 February 2018