(Q47736239)

5 February 2018

title

Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders (English)

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5 February 2018

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Raffaele Riccio

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5 February 2018

author name string

Chiara Cassiano

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5 February 2018

Roberta Esposito

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Alessandra Tosco

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5 February 2018

Maria Valeria D'Auria

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Agostino Casapullo

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Maria Chiara Monti

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5 February 2018

language of work or name

English

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publication date

1 January 2014

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5 February 2018

published in

Chemical Communications

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5 February 2018

volume

50

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5 February 2018

issue

4

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5 February 2018

page(s)

406-408

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5 February 2018

Natural products as sources of new drugs over the last 25 years

cites work

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https://api.crossref.org/works/10.1039%2FC3CC45454A

Target identification for small bioactive molecules: finding the needle in the haystack

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Target profiling of small molecules by chemical proteomics

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Chemical proteomics discloses petrosapongiolide M, an antiinflammatory marine sesterterpene, as a proteasome inhibitor.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3CC45454A

Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor.

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Heat shock proteins as key biological targets of the marine natural cyclopeptide perthamide C.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3CC45454A

Scalarane sesterterpenoids: semisynthesis and biological activity.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3CC45454A

Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3CC45454A

Inhibition of TDP-43 aggregation by nucleic acid binding

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3CC45454A

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3CC45454A

An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3CC45454A

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3CC45454A

RNA granules: post-transcriptional and epigenetic modulators of gene expression

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3CC45454A

Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3CC45454A

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3CC45454A

Development of a novel nonradiometric assay for nucleic acid binding to TDP-43 suitable for high-throughput screening using AlphaScreen technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3CC45454A

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3CC45454A

Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/C3CC45454A

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5 February 2018

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5 February 2018