(Q34589404)

3 August 2017

title

Target identification for small bioactive molecules: finding the needle in the haystack (English)

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3 August 2017

4

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3 August 2017

Slava Ziegler

1

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3 August 2017

Verena Pries

series ordinal

2

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3 August 2017

Christian Hedberg

series ordinal

3

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3 August 2017

language of work or name

English

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publication date

18 February 2013

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Angewandte Chemie International Edition

3 August 2017

published in

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volume

52

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3 August 2017

issue

10

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3 August 2017

page(s)

2744-2792

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Chemical genetics to chemical genomics: small molecules offer big insights

3 August 2017

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Energetics-based discovery of protein-ligand interactions on a proteomic scale

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Analysis of the cGMP/cAMP interactome using a chemical proteomics approach in mammalian heart tissue validates sphingosine kinase type 1-interacting protein as a genuine and highly abundant AKAP.

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Natural products reveal cancer cell dependence on oxysterol-binding proteins

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Natural product–inspired cascade synthesis yields modulators of centrosome integrity

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Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

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A tandem orthogonal proteolysis strategy for high-content chemical proteomics

21 January 2018

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Synthesis of conjugates of 6-aminophenanthridine and guanabenz, two structurally unrelated prion inhibitors, for the determination of their cellular targets by affinity chromatography

21 January 2018

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High-performance affinity beads for identifying drug receptors

21 January 2018

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Design and synthesis of novel hydrophilic spacers for the reduction of nonspecific binding proteins on affinity resins

21 January 2018

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Proteomics evaluation of chemically cleavable activity-based probes

21 January 2018

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Comparative analysis of cleavable azobenzene-based affinity tags for bioorthogonal chemical proteomics

21 January 2018

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Synthesis and application of a new cleavable linker for "click"-based affinity chromatography

21 January 2018

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Useful tools for biomolecule isolation, detection, and identification: acylhydrazone-based cleavable linkers.

21 January 2018

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A cleavable linker based on the levulinoyl ester for activity-based protein profiling

21 January 2018

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Development of a novel chemical probe for the selective enrichment of phosphorylated serine- and threonine-containing peptides

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Duocarmycin analogues target aldehyde dehydrogenase 1 in lung cancer cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Biotin binding to avidin. Oligosaccharide side chain not required for ligand association

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

AVIDIN. 1. THE USE OF (14-C)BIOTIN FOR KINETIC STUDIES AND FOR ASSAY

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Direct identification of ligand-receptor interactions on living cells and tissues

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Activity-based proteome profiling of potential cellular targets of Orlistat--an FDA-approved drug with anti-tumor activities

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Protein reactivity of natural product-derived γ-butyrolactones

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Showdomycin as a versatile chemical tool for the detection of pathogenesis-associated enzymes in bacteria

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Profiling serine hydrolase activities in complex proteomes

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

The FLAG peptide, a versatile fusion tag for the purification of recombinant proteins

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

An immuno-chemo-proteomics method for drug target deconvolution

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Current strategies for the use of affinity tags and tag removal for the purification of recombinant proteins

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Ammosamides A and B target myosin

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Capture of drug targets from live cells using a multipurpose immuno-chemo-proteomics tool

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Copper-catalyzed azide-alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(I) acetylides

21 January 2018

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Capture compound mass spectrometry: a technology for the investigation of small molecule protein interactions

21 January 2018

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Probing small molecule-protein interactions: A new perspective for functional proteomics

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Profiling of methyltransferases and other S-Adenosyl-L-homocysteine-binding proteins by Capture Compound mass spectrometry.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Arabidopsis methyltransferase fingerprints by affinity-based protein profiling.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Synthesis of S-adenosyl-L-homocysteine capture compounds for selective photoinduced isolation of methyltransferases

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Capture compound mass spectrometry sheds light on the molecular mechanisms of liver toxicity of two Parkinson drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Discovery and target identification of an antiproliferative agent in live cells using fluorescence difference in two-dimensional gel electrophoresis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

The natural product avrainvillamide binds to the oncoprotein nucleophosmin

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of drug targets in vitro and in living cells by soluble-nanopolymer-based proteomics

21 January 2018

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A versatile method of identifying specific binding proteins on affinity resins.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

A chemical proteomics based enrichment technique targeting the interactome of the PDE5 inhibitor PF-4540124.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Chemical proteomics reveals bolinaquinone as a clathrin-mediated endocytosis inhibitor.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Small-molecule synergist of the Wnt/beta-catenin signaling pathway

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Discovery and characterization of small molecule inhibitors of the BET family bromodomains

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of a novel protein regulating microtubule stability through a chemical approach

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Actin is the primary cellular receptor of bistramide A.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Dissection of melanogenesis with small molecules identifies prohibitin as a regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Enantiodifferential approach for the detection of the target membrane protein of the jasmonate glycoside that controls the leaf movement of Albizzia saman

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Synthetic small molecules that control stem cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Adenosine Kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of small molecule activators of cryptochrome

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

A small-molecule antagonist of the hedgehog signaling pathway.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Protein stains for proteomic applications: which, when, why?

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Target profiling of small molecules by chemical proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

The quantitative proteome of a human cell line.

21 January 2018

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Deep proteome and transcriptome mapping of a human cancer cell line

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

A natural product inspired tetrahydropyran collection yields mitosis modulators that synergistically target CSE1L and tubulin.

21 January 2018

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Universal sample preparation method for proteome analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Actin microfilament aggregation induced by withaferin A is mediated by annexin II.

21 January 2018

1 reference

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The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I

21 January 2018

1 reference

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Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array

21 January 2018

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Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions.

21 January 2018

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Ligand-directed tosyl chemistry for protein labeling in vivo

21 January 2018

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Marinopyrrole A target elucidation by acyl dye transfer

21 January 2018

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Phosphopeptide-dependent labeling of 14-3-3 ζ proteins by fusicoccin-based fluorescent probes.

21 January 2018

1 reference

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Mass spectrometry-based quantitative proteomic profiling

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Properties of 13C-Substituted Arginine in Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identifying the proteins to which small-molecule probes and drugs bind in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

21 January 2018

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Fully functionalized small-molecule probes for integrated phenotypic screening and target identification

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201208749

Proteomics analysis of cellular imatinib targets and their candidate downstream effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Large-scale proteomics analysis of the human kinome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Stable isotope labeling by amino acids in cell culture (SILAC) and quantitative comparison of the membrane proteomes of self-renewing and differentiating human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Quantitative chemical proteomics for identifying candidate drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Chemical probes and tandem mass spectrometry: a strategy for the quantitative analysis of proteomes and subproteomes

21 January 2018

1 reference

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

21 January 2018

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Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

21 January 2018

1 reference

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Quantitative analysis of the intra- and inter-individual variability of the normal urinary proteome

21 January 2018

1 reference

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Quantitative proteomics reveals subset-specific viral recognition in dendritic cells.

21 January 2018

1 reference

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Quantitative, high-resolution proteomics for data-driven systems biology

21 January 2018

1 reference

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Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present

21 January 2018

1 reference

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Identification of compounds that bind mitochondrial F1F0 ATPase by screening a triazine library for correction of albinism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Microarrays of tagged combinatorial triazine libraries in the discovery of small-molecule ligands of human IgG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of the F1F0 mitochondrial ATPase as a target for modulating skin pigmentation by screening a tagged triazine library in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Forward chemical genetic approach identifies new role for GAPDH in insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Two-dimensional gel electrophoresis in proteomics: Past, present and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

The discovery and mechanism of action of novel tumor-selective and apoptosis-inducing 3,5-diaryl-1,2,4-oxadiazole series using a chemical genetics approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A comparison of immobilized pH gradient isoelectric focusing and strong-cation-exchange chromatography as a first dimension in shotgun proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Target identification using drug affinity responsive target stability (DARTS)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Pulse proteolysis: A simple method for quantitative determination of protein stability and ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Simplified proteomics approach to discover protein-ligand interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

An information-intensive approach to the molecular pharmacology of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the compare program.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

AMF-26, a novel inhibitor of the Golgi system, targeting ADP-ribosylation factor 1 (Arf1) with potential for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Expression profiling identifies epoxy anthraquinone derivative as a DNA topoisomerase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of novel hair-growth inducers by means of connectivity mapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Fluorescent two-dimensional difference gel electrophoresis unveils the potential of gel-based proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Multidimensional drug profiling by automated microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A morphological biosensor for mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Chemical strategies for generating protein biochips

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Protein microarrays: novel developments and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

UPA, a universal protein array system for quantitative detection of protein-protein, protein-DNA, protein-RNA and protein-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Membrane protein microarrays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of novel substrates for Cdk5 and new targets for Cdk5 inhibitors using high-density protein microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Relating protein pharmacology by ligand chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Predicting new molecular targets for known drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A ligand-based approach to mining the chemogenomic space of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

PASS: prediction of activity spectra for biologically active substances

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Yeast-based functional genomics and proteomics technologies: the first 15 years and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Functional profiling of the Saccharomyces cerevisiae genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Barcode technology in yeast: application to pharmacogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Genomic profiling of drug sensitivities via induced haploinsufficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Genome-wide screening of Saccharomyces cerevisiae to identify genes required for antibiotic insusceptibility of eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Genome-wide screen identifies genes whose inactivation confer resistance to cisplatin in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Small ubiquitin-related modifier pathway is a major determinant of doxorubicin cytotoxicity in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A universal TagModule collection for parallel genetic analysis of microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Towards high-throughput characterization of small molecule mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

An integrated platform of genomic assays reveals small-molecule bioactivities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Quantitative phenotyping via deep barcode sequencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Enhancing drug accumulation in Saccharomyces cerevisiae by repression of pleiotropic drug resistance genes with chimeric transcription repressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

shRNA libraries and their use in cancer genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Topoisomerase levels determine chemotherapy responsein vitroandin vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Haploid genetic screens in human cells identify host factors used by pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A functional genomics approach to the mode of action of apratoxin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A novel genetic system to detect protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A three-hybrid system for detecting small ligand-protein receptor interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

MASPIT: three-hybrid trap for quantitative proteome fingerprinting of small molecule-protein interactions in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A Coiled-Coil Enabled Split-Luciferase Three-Hybrid System: Applied Toward Profiling Inhibitors of Protein Kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A three-hybrid approach to scanning the proteome for targets of small molecule kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Phage display systems and their applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

In vitro selection from protein and peptide libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Display of expression products of cDNA libraries on phage surfaces. A versatile screening system for selective isolation of genes by specific gene-product/ligand interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Display cloning: functional identification of natural product receptors using cDNA-phage display

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of hNopp140 as a binding partner for doxorubicin with a phage display cloning method

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Screening of paclitaxel-binding molecules from a library of random peptides displayed on T7 phage particles using paclitaxel-photoimmobilized resin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A new curcumin derivative, HBC, interferes with the cell cycle progression of colon cancer cells via antagonization of the Ca2+/calmodulin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

cDNA phage display as a novel tool to screen for cellular targets of chemical compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Rapid identification of a protein binding partner for the marine natural product kahalalide F by using reverse chemical proteomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Drug receptor identification from multiple tissues using cellular-derived mRNA display libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Luminescent oxygen channeling immunoassay: measurement of particle binding kinetics by chemiluminescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Why molecules move along a temperature gradient

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Label-free microscale thermophoresis discriminates sites and affinity of protein-ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Phosphatidylethanolamine-binding proteins, including RKIP, exhibit affinity for phosphodiesterase-5 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Analysis of Protein−Small Molecule Interactions by Microscale Equilibrium Dialysis and Its Application As a Secondary Confirmation Method for on-Bead Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

An electrochemical sensor for the detection of protein-small molecule interactions directly in serum and other complex matrices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Small-molecule inhibition of APT1 affects Ras localization and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A dumbbell-shaped small molecule that promotes cell adhesion and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Diterpenoids from Isodon adenantha

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Flavinylation of monoamine oxidase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Nucleophosmin is required for chromosome congression, proper mitotic spindle formation, and kinetochore-microtubule attachment in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Structural view of a fungal toxin acting on a 14-3-3 regulatory complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

The metabolic serine hydrolases and their functions in mammalian physiology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Identification of a primary target of thalidomide teratogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

A planning strategy for diversity-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Pursuing the leadlikeness concept in pharmaceutical research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Distributed Drug Discovery, Part 1: linking academia and combinatorial chemistry to find drug leads for developing world diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

Fusicoccin: a New Wilting Toxin produced by Fusicoccum amygdali Del

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201208749

21 January 2018

Identifiers

DOI

10.1002/ANIE.201208749

1 reference

3 August 2017

1 reference