(Q34288305)

1 August 2017

title

Identification of small molecule activators of cryptochrome (English)

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1 August 2017

11

Francis J Doyle

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1 August 2017

Tsuyoshi Hirota

1

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David A. Brenner

object named as

David A Brenner

10

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Peter G. Schultz

12

object named as

Peter G Schultz

1 reference

1 August 2017

Jae Wook Lee

2

1 reference

1 August 2017

Peter C St John

3

1 reference

1 August 2017

Mariko Sawa

4

1 reference

1 August 2017

Keiko Iwaisako

5

1 reference

1 August 2017

Takako Noguchi

6

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1 August 2017

Pagkapol Y Pongsawakul

7

1 reference

1 August 2017

Tim Sonntag

8

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1 August 2017

David K Welsh

9

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1 August 2017

Steve A Kay

13

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1 August 2017

language of work or name

English

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publication date

12 July 2012

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1 August 2017

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1 August 2017

volume

337

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1 August 2017

issue

6098

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1 August 2017

page(s)

1094-1097

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SENSITIVITY ANALYSIS FOR OSCILLATING DYNAMICAL SYSTEMS.

1 August 2017

cites work

1 reference

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Circadian gene variants and susceptibility to type 2 diabetes: a pilot study

6 July 2018

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Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

6 July 2018

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Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening

6 July 2018

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Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

6 July 2018

1 reference

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A small molecule modulates circadian rhythms through phosphorylation of the period protein

6 July 2018

1 reference

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The REV-ERBs and RORs: molecular links between circadian rhythms and lipid homeostasis

6 July 2018

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Crosstalk between components of circadian and metabolic cycles in mammals

6 July 2018

1 reference

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Delay in feedback repression by cryptochrome 1 is required for circadian clock function

6 July 2018

1 reference

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High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase

6 July 2018

1 reference

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Circadian integration of metabolism and energetics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping

6 July 2018

1 reference

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

6 July 2018

1 reference

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Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock

6 July 2018

1 reference

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High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms.

6 July 2018

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A genome-wide RNAi screen for modifiers of the circadian clock in human cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

A model of the cell-autonomous mammalian circadian clock

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

6 July 2018

The meter of metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

Intercellular coupling confers robustness against mutations in the SCN circadian clock network

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

Toward a detailed computational model for the mammalian circadian clock

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

A combinatorial scaffold approach toward kinase-directed heterocycle libraries

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

Posttranslational mechanisms regulate the mammalian circadian clock

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

Light-independent role of CRY1 and CRY2 in the mammalian circadian clock.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

An intein-cassette integration approach used for the generation of a split TEV protease activated by conditional protein splicing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589997

28 October 2018

Identifiers

DOI

10.1126/SCIENCE.1223710

1 reference

1 August 2017

1 reference

1 August 2017

1 reference