(Q47796440)

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Peroxisome proliferator-activated receptors target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/15072437

Peroxisome proliferator-activated receptors target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis (English)

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/15072437

author name string

Bernard Pirard

1

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/15072437

publication date

1 November 2003

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/15072437

Journal of Computer - Aided Molecular Design

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/15072437

17

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/15072437

11

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/15072437

785-796

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/15072437

https://scigraph.springernature.com/pub.10.1023/b:jcam.0000017498.74580.3d

0 references

The PPARs: from orphan receptors to drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Collecting and harvesting biological data: the GPCRDB and NucleaRDB information systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Binding of ligands and activation of transcription by nuclear receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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A Novel Strategy for Improving Ligand Selectivity in Receptor-Based Drug Design

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Insulin-sensitising agents: beyond thiazolidinediones

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Chemometric rationalization of the structural and physicochemical basis for selective cyclooxygenase-2 inhibition: toward more specific ligands.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Nuclear receptors and lipid physiology: opening the X-files

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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A search for specificity in DNA-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

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18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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GRID/CPCA: a new computational tool to design selective ligands.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Affinity and selectivity of matrix metalloproteinase inhibitors: a chemometrical study from the perspective of ligands and proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

based on heuristic

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A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of selective regions in the active sites of human cytochromes P450, 2C8, 2C9, 2C18, and 2C19 homology models using GRID/CPCA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear-receptor ligands and ligand-binding domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

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Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Structural classification of protein kinases using 3D molecular interaction field analysis of their ligand binding sites: target family landscapes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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Novel insulin sensitizers: pharmacogenomic aspects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

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A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural Differences of Matrix Metalloproteinases with Potential Implications for Inhibitor Selectivity Examined by the GRID/CPCA Approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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The sensitivity of the results of molecular docking to induced fit effects: application to thrombin, thermolysin and neuraminidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

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(-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of Relibase for retrieving complex three-dimensional interaction patterns including crystallographic packing effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular recognition of fatty acids by peroxisome proliferator-activated receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family

1 reference

https://pubmed.ncbi.nlm.nih.gov/15072437

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/B:JCAM.0000017498.74580.3D

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/15072437

DBLP publication ID

journals/jcamd/Pirard03

1 reference

DBLP Dataset 2021-01-02

28 January 2021

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 February 2018

http://europepmc.org/abstract/MED/15072437

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